folic acid antagonist

folic acid antagonist
an antimetabolite of folic acid; those used as chemotherapeutic agents are competitive inhibitors of dihydrofolate reductase: trimethoprim is used as an antibacterial, pyrimethamine as an antimalarial, and methotrexate as an antineoplastic. Called also antifol and antifolate.

Medical dictionary. 2011.

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