apoptosome

apoptosome
apop·to·some (ə-popґtə-sōm) [apoptosis + -some] a complex of apoptotic protease activating factor 1 (Apaf-1), caspase 9, cytochrome c>, and other proteins; it is formed when deoxyadenosine triphosphate (dATP) and cytochrome c (released from mitochondria) bind to the C-terminal of and activate Apaf-1, which in turn binds and activates caspase 9. Caspase 9 activates caspase 3 and initiates a cascade that results in apoptosis.

Medical dictionary. 2011.

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  • Apoptosome — The apoptosome is a large ternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death… …   Wikipedia

  • Apoptosome — Le complexe de l apoptosome intervient dans le mécanisme intrinsèque de l apoptose. Il est formé à partir d une protéine APAF1, de deux procaspase 9 et de deux protéines cytochrome C libérés par la mitochondrie. Un fois le complexe formé, il… …   Wikipédia en Français

  • apoptosome — noun A large ternary protein structure formed in the process of apoptosis …   Wiktionary

  • Apoptosis — (IPA en|ˌæpəpˈtoʊsəs [ [http://www.webster.com/dictionary/apoptosis Webster.com dictionary entry] ] ) is a form of programmed cell death in multicellular organisms. It is one of the main types of programmed cell death (PCD) and involves a series… …   Wikipedia

  • Hsp70 — protein Structure of the ATPase fragment of a 70K heat shock cognate protein.[1] Identifiers Symbol …   Wikipedia

  • APAF1 — Apoptotic peptidase activating factor 1, also known as APAF1, is a human gene. PBB Summary section title = summary text = This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD 40 domain,… …   Wikipedia

  • Caspase — Caspases, or c ysteine asp artic acid prote ases , are a family of cysteine proteases, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation. Caspases are essential in cells for apoptosis, one of the main… …   Wikipedia

  • Apaf-1 — (apoptotic protease activating factor 1) is a cytosolic protein involved in cell death or apoptosis. When Cytochrome c is released from the mitochondria, it interacts with Apaf 1 and dATP to form the apoptosome, a large oligomeric protein complex …   Wikipedia

  • Deleted in Colorectal Cancer — Deleted in colorectal carcinoma Rendering based on PDB 2ED7 …   Wikipedia

  • Caspase-9 — Caspase 9, apoptosis related cysteine peptidase PDB rendering based on 1jxq …   Wikipedia

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