- Inhibitor of xanthine oxidase to inhibit uric acid formation; used in the treatment of gout and to retard the rapid metabolic degradation of 6-mercaptopurine.
* * *al·lo·pu·ri·nol .al-ō-'pyu̇r-ə-.nȯl, -.nōl n a drug C3H4N4O used to promote excretion of uric acid esp. in the treatment of gout
* * *n.a drug used in the treatment of chronic gout. It acts by reducing the level of uric acid in tissues and blood. It is administered by mouth; side-effects include nausea, vomiting, diarrhoea, headache, fever, stomach pains, and skin rashes. Occasionally, nerve damage and enlargement of the liver may occur. Trade name: Zyloric.
* * *al·lo·pur·i·nol (al″o-pūrґĭ-nol) [USP] an isomer of hypoxanthine; used in the treatment of hyperuricemia of gout and the prophylaxis and treatment of that secondary to blood dyscrasias or cancer chemotherapy, for prophylaxis of recurrent formation of uric acid and oxalate renal calculi, and for prophylaxis and treatment of uric acid nephropathy. Both allopurinol and its primary metabolite, oxypurinol, are potent inhibitors of xanthine oxidase and reduce serum levels and urinary excretion of uric acid.
Medical dictionary. 2011.