HMG box

HMG box
a DNA-binding motif of approximately 75 amino acids, occurring in pairs in HMG-1/2 (high mobility group) proteins, and also found in other transcription factors with varying specificities but having in common an ability to distort DNA and an affinity for binding distorted DNA.

Medical dictionary. 2011.

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  • HMG-box — Pfam box Symbol = PF00505 Name = HMG (high mobility group) box width = 300px caption = NMR structure of the HMG box domain of the LEF1 protein (rainbow colored, N terminus = blue, C terminus = red) complexed with DNA (brown) based on the PDB|2LEF …   Wikipedia

  • HBP1 — HMG box transcription factor 1, also known as HBP1, is a human protein.cite web | title = Entrez Gene: HBP1 HMG box transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=26959| accessdate …   Wikipedia

  • high mobility group proteins — HMG proteins a highly conserved family of small nonhistone nucleoproteins that bind DNA and are involved in controlling transcription. They are important for growth and development, and are regulated by cell cycle–dependent phosphorylation.… …   Medical dictionary

  • TOX — Thymocyte selection associated high mobility group box gene, also known as TOX, is a human gene.cite web | title = Entrez Gene: thymocyte selection associated high mobility group box gene TOX| url =… …   Wikipedia

  • SOX genes — encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super family of genes characterized by a homologous sequence called the HMG (high mobility group) box. This HMG box is a DNA binding domain that is… …   Wikipedia

  • High mobility group — or HMG is a group of chromosomal proteins that help with transcription, replication, recombination, and DNA repair.cite journal | author = Rajeswari MR, Jain A | title = High mobility group chromosomal proteins, HMGA1 as potential tumour markers… …   Wikipedia

  • SOX4 — SRY (sex determining region Y) box 4, also known as SOX4, is a human gene.cite web | title = Entrez Gene: SOX4 SRY (sex determining region Y) box 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6659|… …   Wikipedia

  • TCF7 — Transcription factor 7 (T cell specific, HMG box), also known as TCF7, is a human gene.cite web | title = Entrez Gene: TCF7 transcription factor 7 (T cell specific, HMG box)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • TOX2 — protein Name = TOX high mobility group box family member 2 caption = width = HGNCid = 16095 Symbol = TOX2 AltSymbols = C20orf100, GCX 1 EntrezGene = 84969 OMIM = 611163 RefSeq = NM 001098796 UniProt = Q96NM4 PDB = ECnumber = Chromosome = 20 Arm …   Wikipedia

  • SOX12 — SRY (sex determining region Y) box 12, also known as SOX12, is a human gene.cite web | title = Entrez Gene: SOX12 SRY (sex determining region Y) box 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6666|… …   Wikipedia

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