hereditary nonpolyposis colorectal cancer
- hereditary nonpolyposis colorectal cancer
- (HNPCC) a group of hereditary, autosomal dominant cancers characterized by discrete adenomas of the colon and rectum without polyposis. Two types have been distinguished: in type 1, all affected persons have colorectal cancers; in type 2, some family members have cancer in other parts of the body, such as the female genital tract, stomach, brain, breast, or urinary tract. Both types are caused by mutations in mismatch repair genes, particularly MSH2 (locus: 2p22-p21) and MLH1 (locus: 3p21.3), and are characterized by microsatellite instability. Called also Lynch syndrome. Type 2 is also called cancer family syndrome.
Medical dictionary.
2011.
Look at other dictionaries:
Hereditary nonpolyposis colorectal cancer — Classification and external resources ICD 10 C18 C20 ICD 9 … Wikipedia
hereditary nonpolyposis colorectal cancer — HNPCC an inherited disorder in which there is an increased incidence of colorectal polyp formation, although to a lesser extent than in familial adenomatous polyposis (FAP). HNPCC has also been associated with other types of tumour, particularly… … The new mediacal dictionary
hereditary nonpolyposis colon cancer — HNPCC. An inherited disorder in which affected individuals have a higher than normal chance of developing colorectal cancer and certain other types of cancer, often before the age of 50. Also called HNPCC and Lynch syndrome … English dictionary of cancer terms
Colorectal cancer — Classification and external resources Diagram of the lower gastrointestinal tract ICD 10 C … Wikipedia
colorectal cancer — Malignant tumour of the large intestine (colon) or rectum. Risk factors include age (after age 50), family history of colorectal cancer, chronic inflammatory bowel diseases, benign polyps, physical inactivity, and a diet high in fat. Many of the… … Universalium
Cancer Colorectal Héréditaire Sans Polypose — Autre nom Syndrome de Lynch Syndrome de Turcot HNPCC Référence MIM … Wikipédia en Français
Cancer colorectal hereditaire sans polypose — Cancer colorectal héréditaire sans polypose Cancer colorectal héréditaire sans polypose Autre nom Syndrome de Lynch Syndrome de Turcot HNPCC Référence MIM … Wikipédia en Français
Cancer colorectal héréditaire sans polypose (HNPCC) — Cancer colorectal héréditaire sans polypose Cancer colorectal héréditaire sans polypose Autre nom Syndrome de Lynch Syndrome de Turcot HNPCC Référence MIM … Wikipédia en Français
Cancer colorectal héréditaire sans polypose — Référence MIM 120435 Transmission Dominante Chromosome Voir article Gène Voir article Mutation de novo Possible … Wikipédia en Français
Cancer — For other uses, see Cancer (disambiguation). Cancer Classification and external resources … Wikipedia
