dystrophin-glycoprotein complex
- dystrophin-glycoprotein complex
- (DGC) a large oligomeric complex of proteins and glycoproteins of the sarcolemma that are critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix; it includes dystrophin, sarcoglycans, dystroglycans, sarcospan, syntrophins, and dystrobrevin. Abnormalities of the plasma membrane of the muscle fiber that destroy this complex have been associated with several types of muscular dystrophy and with cardiomyopathy.
Medical dictionary.
2011.
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Dystrophin — is a rod shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. This complex is variously known as the costamere or the … Wikipedia
dystrophin — A protein found in the sarcolemma of normal muscle; it is missing in individuals with pseudohypertrophic muscular dystrophy and in other forms of muscular dystrophy; its role may be in the linkage of the … Medical dictionary
dystrophin — ˈdistrəˌfin noun ( s) Etymology: dystrophy + in : a protein of high molecular weight that is associated with a transmembrane glycoprotein complex of skeletal muscle cells and is absent in Duchenne muscular dystrophy and deficient or of abnormal… … Useful english dictionary
SGCB — Sarcoglycan, beta (43kDa dystrophin associated glycoprotein), also known as SGCB, is a human gene.cite web | title = Entrez Gene: SGCB sarcoglycan, beta (43kDa dystrophin associated glycoprotein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db … Wikipedia
SGCD — Sarcoglycan, delta (35kDa dystrophin associated glycoprotein), also known as SGCD, is a human gene.cite web | title = Entrez Gene: SGCD sarcoglycan, delta (35kDa dystrophin associated glycoprotein)| url =… … Wikipedia
Muscular dystrophy — Classification and external resources ICD 10 G71.0 ICD 9 359.0 … Wikipedia
SGCA — Sarcoglycan, alpha (50kDa dystrophin associated glycoprotein), also known as SGCA, is a human gene.cite web | title = Entrez Gene: SGCA sarcoglycan, alpha (50kDa dystrophin associated glycoprotein)| url =… … Wikipedia
DTNA — Dystrobrevin, alpha Identifiers Symbols DTNA; D18S892E; DRP3; DTN; DTN A; FLJ96209; LVNC1 External IDs … Wikipedia
DTNB — This article is about the DTNB gene and protein. For the chemical substance, see Ellman s reagent. Dystrobrevin, beta Identifiers Symbols DTNB; MGC17163; MGC57126 … Wikipedia
Utrophin — Utrophin, also known as UTRN, is a human gene.cite web | title = Entrez Gene: UTRN utrophin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7402| accessdate = ] The protein encoded by this gene is a… … Wikipedia
