Darier disease

Darier disease
Darier-White disease a slowly progressive, autosomal dominant disorder of keratinization caused by mutation in the ATP2A2 gene (locus: 12q23-q24.1), which encodes a calcium-transporting ATPase of the sarcoplasmic reticulum. It is characterized by pink to tan or skin-colored papules on seborrheic areas of the body. The papules later coalesce to form plaques that may become crusted, infected, and foul-smelling; over time the lesions may become darker and fuse to form papillomatous or warty growths. Called also follicular keratosis and keratosis follicularis.

Medical dictionary. 2011.

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  • Darier disease — Darier disease. См. фолликулярный дискератоз. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Darier disease sign — Da·rier disease, sign (dah re aґ) [Jean Ferdinand Darier, French dermatologist, 1856–1938] see under disease and sign …   Medical dictionary

  • Darier's disease — Classification and external resources Linear Darier s disease ICD 10 Q82.8 …   Wikipedia

  • Darier's disease — Da·rier s disease dar yāz , där n a genetically determined skin condition characterized by patches of keratotic papules called also keratosis follicularis Da·rier dȧr yā Jean Ferdinand (1856 1938) French dermatologist. Darier is known for… …   Medical dictionary

  • Darier-White disease — Da·rier White disease (dah re aґ hwītґ) [J.F. Darier; James Clarke White, American dermatologist, 1833–1916] see under disease …   Medical dictionary

  • Darier's disease — noun a rare hereditary condition marked by dark crusted patches (sometimes containing pus) • Syn: ↑keratosis follicularis • Hypernyms: ↑keratosis * * * där¦yāz, dȧ(r) noun Usage: usually capitalized 1st D Etymology: a …   Useful english dictionary

  • Disease — Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the… …   Medical dictionary

  • Darier — Jean F., French dermatologist, 1856–1938. See D. disease, D. sign …   Medical dictionary

  • Ferdinand-Jean Darier — Born 26 April 1856(1856 04 26) Budapest, Hungary Died 1938 (aged 81–82) Paris, France[citation needed] …   Wikipedia

  • Wilson's disease — Classification and external resources A Kayser Fleischer ring (the brown ring on the edge of the iris) is common in Wilson s disease, especially when neurological symptoms are present ICD …   Wikipedia

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