aprotinin

aprotinin
A protease and kallikrein inhibitor obtained from animal organs; a polypeptide with a molecular weight of about 6000. May be useful in the treatment of pancreatitis and in preventing bleeding after surgery involving cardiopulmonary bypass.

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apro·ti·nin ā-'prōt-ə-nin n a polypeptide used for its protease-inhibiting properties esp. in the treatment of pancreatitis see TRASYLOL

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n.
a drug that prevents the breakdown of blood clots (see fibrinolysis) by blocking the action of the enzyme plasmin, i.e. it is an antifibrinolytic drug. It is administered by injection to control the severe bleeding that may occur in certain cancers, with fibrinolytic treatments, and during open-heart surgery. Trade name: Trasylol.

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apro·ti·nin (ap″ro-tiґnin) [USP] a single-chain polypeptide of the serpin group that inhibits multiple mediators, resulting in attenuation of inflammatory responses, of fibrinolysis, and of thrombin generation; used as an antihemorrhagic to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft; administered intravenously.

Medical dictionary. 2011.

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Look at other dictionaries:

  • Aprotinin — drugbox IUPAC name = Aprotinin width = 181 CAS number = 9087 70 1 ATC prefix = B02 ATC suffix = AB01 PubChem = N/A DrugBank = chemical formula = C=284 | H=432 | N=84 | I= | Br= | Cl= | F= | O=79 | P= | S=7 | Se= | Na= molecular weight = 6511.51… …   Wikipedia

  • Aprotinin — Pankreatischer Trypsin Inhibitor (Bos taurus) Vorhandene Strukturdaten: s. UniProt …   Deutsch Wikipedia

  • Aprotinin — …   Википедия

  • aprotinin — Basic polypeptide that inhibits several serine proteases (including trypsin, chymotrypsin, kallikrein, pepsin) …   Dictionary of molecular biology

  • aprotinin — a·pro·ti·nin (ā prōtʹn ĭn, ă prōtʹ ) n. A natural polypeptide and protease inhibitor that affects blood clotting and is used during high risk surgery, such as cardiopulmonary bypass, to reduce bleeding.   [a 1 + proteinase + in.] * * * …   Universalium

  • aprotinin — noun A polypeptide, obtained from bovine lung tissue, that acts as a protease inhibitor, and is used in surgery to reduce bleeding …   Wiktionary

  • Aprotinin — A|pro|ti|nin: ein körpereigenes, aus 58 Aminosäuren aufgebautes ↑ Serpin, das gegen Blutungen u. Schock eingesetzt werden kann …   Universal-Lexikon

  • aprotinin — n. a drug that prevents the breakdown of blood clots (see fibrinolysis) by blocking the action of the enzyme plasmin, i.e. it is an antifibrinolytic drug. It is administered by injection to control the severe bleeding that may occur in certain… …   The new mediacal dictionary

  • Апротинин (Aprotinin) — лекарственное вещество, предотвращающее рассасывание тромбов (см. Фибринолиз) путем блокирования действия плазмина (антифибринолитичсское средство (antifibrinolytic drag)). Назначается в инъекциях для остановки сильных кровотечений, которые имеют …   Медицинские термины

  • АПРОТИНИН — (aprotinin) лекарственное вещество, предотвращающее рассасывание тромбов (см. Фибринолиз) путем блокирования действия плазмина (антифибринолитичсское средство (antifibrinolytic drag)). Назначается в инъекциях для остановки сильных кровотечений,… …   Толковый словарь по медицине

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