colony-stimulating factors

colony-stimulating factors
a group of glycoprotein lymphokine growth factors produced by blood monocytes, tissue macrophages, and stimulated lymphocytes; they are required for differentiation of stem cells into granulocyte and monocyte cell colonies, and were originally named according to their ability to stimulate the production of morphologically distinguishable myeloid cell colonies in vitro. In vivo, they stimulate the production of granulocytes and macrophages and enhance the actions of mature cells. Colony-stimulating factors can be produced by recombinant DNA techniques and have been used experimentally as anticancer agents and for the restoration of hematopoietic function after myelosuppression in transplantation and cancer chemotherapy.

Medical dictionary. 2011.

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  • CSF (colony-stimulating factor) — A laboratory made agent similar to a substance in the body that stimulates the production of blood cells. The colony stimulating factors (CSFs) include granulocyte colony stimulating factor (G CSF) and granulocyte macrophage colony stimulating… …   Medical dictionary

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