thyroid-stimulating immunoglobulins

thyroid-stimulating immunoglobulins
(TSI) circulating IgG antibodies with the ability to mimic thyrotropin by binding to receptors for it on thyroid cells and activating adenylate cyclase, thus causing an increase in the level of the intracellular second messenger cyclic AMP, which results in the release of thyroid hormones; thought to be responsible for most cases of Graves disease. Called also human thyroid adenylate cyclase stimulators (HTACS). Formerly called long-acting thyroid stimulator.

Medical dictionary. 2011.

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  • Thyroid stimulating immunoglobulins — Maladie de Basedow Maladie de Basedow CIM 10 : E05.0 La maladie de Basedow ou Graves Basedow, est une thyroïdite, une maladie auto immune de la thyroïde provoquant une hyperthyroïdie accompagnée de signes cliniques spécifiques. Il s agit de sa… …   Wikipédia en Français

  • long-acting thyroid stimulator — long act·ing thyroid stimulator lȯŋ akt iŋ n a protein that often occurs in the plasma of patients with Graves disease and that is an IgG immunoglobulin abbr. LATS * * * (LATS) the original name given to thyroid stimulating immunoglobulins,… …   Medical dictionary

  • human thyroid adenylate cyclase stimulators — (HTACS) thyroid stimulating immunoglobulins …   Medical dictionary

  • Graves' disease — Classification and external resources Photo showing the classic finding of proptosis and lid retraction in Graves disease ICD 10 …   Wikipedia

  • Immunoglobulin — A protein produced by plasma cells and lymphocytes. Immunoglobulins are an essential part of the body s immune system which attach to foreign substances, such as bacteria, and assist in destroying them. Abbreviated Ig. The classes of… …   Medical dictionary

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  • TSI — Stands for Thyroid Stimulating Immunoglobulin. The TSI level is abnormally high in persons with hyperthyroidism (too much thyroid hormone) due to Graves’ disease. Thyroid hormones are essential for the function of every cell in the body.… …   Medical dictionary

  • Hyperthyroïdie — Classification et ressources externes Triiodothyronine (T3, ci dessus) et thyroxine (T4) sont les deux types d hormones thyroïdiennes …   Wikipédia en Français

  • Graves disease — a syndrome of diffuse hyperplasia of the thyroid, with a female predominance; it usually has an autoimmune etiology and has been linked to autoimmune thyroiditis. Characteristics include hyperthyroidism (q.v.), usually with goiter and ophthalmic… …   Medical dictionary

  • Maladie De Basedow — CIM 10 : E05.0 La maladie de Basedow ou Graves Basedow, est une thyroïdite, une maladie auto immune de la thyroïde provoquant une hyperthyroïdie accompagnée de signes cliniques spécifiques. Il s agit de sa forme la plus fréquente. Elle doit son… …   Wikipédia en Français

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