competitive inhibition

competitive inhibition
inhibition of enzyme activity in which the inhibitor (substrate analogue) reversibly combines with catalytic sites, thus competing with the substrate for binding on the enzyme. The inhibition is reversible since it can be overcome by increasing the substrate concentration. Similarly, the reversible binding of a physiologic antagonist to a receptor site for a hormone or neurotransmitter.

Medical dictionary. 2011.

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  • Competitive inhibition — is a form of enzyme inhibition where binding of the inhibitor to the active site on the enzyme prevents binding of the substrate and vice versa. Contents 1 Mechanism 2 Equation 3 Derivation 4 …   Wikipedia

  • competitive inhibition — Inhibitor that occupies the active site of an enzyme or the binding site of a receptor and prevents the normal substrate or ligand from binding. At sufficiently high concentration of the normal ligand inhibition is lost: the Km is altered by the… …   Dictionary of molecular biology

  • Non-competitive inhibition — is a type of enzyme inhibition where the inhibitor reduces the activity of the enzyme, by binding not to the active site on the enzyme, but to a different site.[1] More specifically, it is a special instance of mixed inhibition where the… …   Wikipedia

  • inhibition — /in i bish euhn, in hi /, n. 1. the act of inhibiting. 2. the state of being inhibited. 3. something that inhibits; constraint. 4. Psychol. a. the blocking or holding back of one psychological process by another. b. inappropriate conscious or… …   Universalium

  • competitive — adjective Date: 1829 1. relating to, characterized by, or based on competition < competitive sports > 2. inclined, desiring, or suited to compete < a competitive personality > < salary benefits must be competitive M. S. Eisenhower > 3. depending… …   New Collegiate Dictionary

  • competitive — com·pet·i·tive kəm pet ət iv adj depending for effectiveness on the relative concentration of two or more substances <competitive inhibition of an enzyme> <competitive protein binding> com·pet·i·tive·ly adv …   Medical dictionary

  • inhibition — 1. Depression or arrest of a function. SEE ALSO: inhibitor. 2. In psychoanalysis, the restraining of instinctual or unconscious drives or tendencies, especially if they conflict with one s conscience or with societal demands. 3. In psychology, a… …   Medical dictionary

  • Competitive exclusion principle — In ecology, the competitive exclusion principle,[1] sometimes referred to as Gause s law of competitive exclusion or just Gause s law,[2] is a proposition which states that two species competing for the same resources cannot coexist if other… …   Wikipedia

  • Mixed inhibition — refers to a combination of two different types of reversible enzyme inhibition – competitive inhibition and uncompetitive inhibition. The term mixed is used when the inhibitor can bind to either the free enzyme or the enzyme substrate complex. In …   Wikipedia

  • Suicide inhibition — Suicide inhibition, also known as suicide inactivation or mechanism based inhibition, is a form of irreversible enzyme inhibition that occurs when an enzyme binds a substrate analogue and forms an irreversible complex with it through a covalent… …   Wikipedia

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