bicuculline

bicuculline
An alkaloid naturally occurring in the d-form; found in Dicentra cucullaria and Adlumia fungosa (family Fumariaceae) and several Corydalis species; a powerful convulsant that acts by antagonizing γ-aminobutyric acid, an inhibitory neurotransmitter.

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bi·cu·cul·line bī-'ku̇k-yə-.lēn, -lən n a convulsant alkaloid C20H17NO6 obtained from plants (family Fumariaceae) and having the capacity to antagonize the action of gamma-aminobutyric acid in the central nervous system

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bi·cu·cul·line (bi-kooґkə-lēn″) an alkaloid neurotoxin found in species of Corydalis, Dicentra, and other plants; it is a convulsant and acts as an antagonist to the inhibitory neurotransmitter γ-aminobutyric acid.

Medical dictionary. 2011.

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  • Bicuculline — drugbox IUPAC name = Bicuculline width = 200 height = 150 CAS number = 485 49 4 ATC prefix = ATC suffix = ATC supplemental = PubChem = 10237 DrugBank = smiles = C1=C6C(=CC2=C1CCN( [C@@H] 2 [C@H] 3C4C(C(O3)=O)C5=C(C=C4)OCO5)C)OCO6 C=20 | H=17 |… …   Wikipedia

  • bicuculline — From Dicentra cucullaria and herbs of the genus Corydalis. Specific blocking agent for the action of the amino acid transmitter g aminobutyric acid (GABA). See amino acid transmitter; amino acid receptor superfamily, GABA receptor …   Dictionary of molecular biology

  • bicuculline — noun A light sensitive competitive antagonist of GABA receptors; it is used in the study of epilepsy …   Wiktionary

  • bicuculline — bi·cu·cul·line …   English syllables

  • bicuculline — (ˈ)bī¦k(y)ükyəˌlēn, lə̇n noun ( s) Etymology: bi (I) + cucull (from cucullaria, specific epithet of Dicentra cucullaria, Dutchman s breeches, in which the substance occurs) + ine : a convulsant alkaloid C20H17 …   Useful english dictionary

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