CCD (cleidocranial dysostosis)

CCD (cleidocranial dysostosis)
A genetic (inherited) disorder of bone development characterized by: {{}}Absent or incompletely formed collar bones (the “cleido-“ part refers to the clavicles, the collar bones) The child with this disorder can bring its shoulders together or nearly so. Typical cranial and facial abnormalities with square skull, late closure of the sutures of the skull, late closure of the fontanels (the soft spots), low nasal bridge, delayed eruption of the teeth, abnormal permanent teeth, etc. The disorder is transmitted in an autosomal dominant manner. A parent with the condition has a 50:50 chance that each of their children will have the condition. Boys and girls stand an equal chance of being affected. The gene for the condition has been found on chromosome 6 (specifically, in band p21). The gene is for the transcription factor CBFA1 (core-binding factor alpha subunit 1). Mutations of CBFA1 cause this disorder. A possible example of this disorder has been found in the skull of a Neanderthal man.

Medical dictionary. 2011.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Cleidocranial dysostosis — Classification and external resources Hypoplasia of the clavicles and bell shaped rib cage in the patient with CDD ICD 10 Q …   Wikipedia

  • CCD — can stand for:Science *Carbonate Compensation Depth, a property of oceans *Colony Collapse Disorder, a phenomenon involving the abrupt disappearance of the worker bees in a beehive or Western honey bee colony *Conceptual Common Denominator, the… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”