pyruvate dehydrogenase (acetyl-transferring)

pyruvate dehydrogenase (acetyl-transferring)
py·ru·vate de·hy·dro·gen·ase (ac·e·tyl-trans·fer·ring) (piґroo-vāt de-hiґdro-jən-ās asґə-təl transґfər-ing) [EC 1.2.4.1] an enzyme of the oxidoreductase class that is a component of the multienzyme pyruvate dehydrogenase complex (q.v.). The enzyme catalyzes the oxidative decarboxylation of pyruvate, forming acetyl bound to the cofactor thiamine pyrophosphate; the acetyl is subsequently transferred to the lipoamide linked to the side chain of a lysine residue of the enzyme dihydrolipoyllysine-residue acetyltransferase, which is also part of the complex. Deficiency of the enzyme causes lacticacidemia, ataxia, psychomotor retardation, and sometimes lactic acidosis.

Medical dictionary. 2011.

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  • Pyruvate dehydrogenase (acetyl-transferring) — In enzymology, a pyruvate dehydrogenase (acetyl transferring) (EC number|1.2.4.1) is an enzyme that catalyzes the chemical reaction:pyruvate + [dihydrolipoyllysine residue acetyltransferase] lipoyllysine ightleftharpoons [dihydrolipoyllysine… …   Wikipedia

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  • Pyruvate dehydrogenase complex — (PDC) is a complex of three enzymes that transform pyruvate into acetyl CoA by a process called pyruvate decarboxylation. Acetyl CoA may then be used in the citric acid cycle to carry out cellular respiration, and this complex links the… …   Wikipedia

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