Chromosome duplication
Part of a chromosome in duplicate. A particular kind of mutation involving the production of one or more copies of any piece of DNA, including sometimes a gene or even an entire chromosome. A duplication is the opposite of a deletion. Duplications have been important in the evolution of the human genome (and the genomes of many other organisms). Duplications typically arise from an event termed unequal crossing-over (recombination) that occurs between misaligned homologous chromosomes during meiosis (germ cell formation). The chance of this event happening is a function of the degree of sharing of repetitive elements between two chromosomes. The recombination products of such an event are a duplication at the site of the exchange and a reciprocal deletion. A remarkable class of duplications in which the duplicated region has popped up far away from home base has also been discovered.

Medical dictionary. 2011.

Look at other dictionaries:

  • Control of chromosome duplication — A key feature of the DNA replication mechanism in eukaryotes is that it is designed to replicate relatively large genomes rapidly and with high fidelity. Replication is initiated at multiple origins of replication on multiple chromosomes… …   Wikipedia

  • Chromosome — For a non technical introduction to the topic, see Introduction to genetics. Diagram of a replicated and condensed metaphase eukaryotic chromosome. (1) Chromatid – one of the two identical parts of the chromosome after S phase. (2)… …   Wikipedia

  • Duplication (Génétique) — En génétique, la duplication génique correspond à la multiplication de matériel génétique sur un chromosome. Il existe plusieurs mécanismes qui résultent à la duplication soit d´une large portion chromosomique, soit d´un gène ou bien de quelques… …   Wikipédia en Français

  • Duplication (genetique) — Duplication (génétique) En génétique, la duplication génique correspond à la multiplication de matériel génétique sur un chromosome. Il existe plusieurs mécanismes qui résultent à la duplication soit d´une large portion chromosomique, soit d´un… …   Wikipédia en Français

  • duplication — [ dyplikasjɔ̃ ] n. f. • XIIIe; lat. duplicatio → double 1 ♦ Vx ou didact. Opération par laquelle on double (une quantité, un volume). Duplication du cube : construction d un cube double d un autre. 2 ♦ Biol. Action de doubler (intr.). Duplication …   Encyclopédie Universelle

  • Chromosome 21 (human) — Chromosome 21 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. The trisomy of the 21st chromosome causes Down Syndrome. Chromosome 21 is the smallest human chromosome, 47 million nucleotides… …   Wikipedia

  • Chromosome 15q trisomy — is an extremely rare genetic disorder, caused by a chromosomal aberration in which there is an excess copy of the long ( q ) arm of human chromosome 15. The disorder is also known as Distal Duplication 15q and Partial Duplication 15q Syndrome.… …   Wikipedia

  • Chromosome acrocentrique — Chromosome Description de la structure d’un chromosome. Le chromosome est l élement porteur de l information génétique. Les chromosomes contiennent les gènes et permettent leur distribution égale dans les deux cellules filles lors de la division… …   Wikipédia en Français

  • Chromosome 8 (human) — Chromosome 8 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 8 spans about 145 million base pairs (the building material of DNA) and represents between 4.5 and 5.0% of the total DNA… …   Wikipedia

  • Chromosome 5q deletion syndrome — Classification and external resources Photomicrograph of bone marrow showing abnormal mononuclear megakaryocytes typical of 5q syndrome ICD O: M …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”