Addison disease
Long-term underfunction of the outer portion of the adrenal gland. In medical terms, chronic insufficiency of the adrenal cortex. This may be due to a number of different insults to the adrenal including physical trauma, hemorrhage, and tuberculosis of the adrenal, and destruction of the cells in the pituitary gland that secrete ACTH (adrenocorticotropic hormone) which normally drives the adrenal. Addison’s disease is characterized by bronzing of the skin, anemia, weakness, and low blood pressure. The U.S. President J.F. Kennedy is said to have had Addison disease. Named after the British physician Thomas Addison (1793-1860).When Addison first identified adrenal insufficiency in 1849, tuberculosis (TB) was responsible for 70-90% of cases. As the treatment for TB improved, the incidence of adrenal insufficiency due to TB of the adrenal glands greatly decreased. TB now accounts for around 20% of cases of primary adrenal insufficiency in developed countries.

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Ad·di·son disease (adґĭ-sən) [Thomas Addison, English physician, 1793–1860] see under disease.

Medical dictionary. 2011.

Look at other dictionaries:

  • Addison disease — Disease in which gradual atrophy of the adrenal cortex causes the adrenal glands to produce insufficient quantities of the steroid hydrocortisone while causing the pituitary gland to produce excess quantities of pituitary hormones. Most of the… …   Universalium

  • Addison disease — Addison disease. См. болезнь Аддисона. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Addison's disease — Classification and external resources ICD 10 E27.1 E27.2 ICD 9 …   Wikipedia

  • Disease, Addison — Long term underfunction of the outer portion of the adrenal gland. In medical terms, chronic insufficiency of the adrenal cortex. This may be due to a number of different insults to the adrenal including physical trauma, hemorrhage, and… …   Medical dictionary

  • disease — diseasedly, adv. diseasedness, n. /di zeez /, n., v., diseased, diseasing. n. 1. a disordered or incorrectly functioning organ, part, structure, or system of the body resulting from the effect of genetic or developmental errors, infection,… …   Universalium

  • Addison — may mean:PlacesCanada*Addison, OntarioUnited States*Addison, Alabama *Addison, Connecticut *Addison, Illinois *Addison, Kentucky *Addison, Maine *Addison, Michigan *Addison (town), New York **Addison (village), New York *Addison, Ohio *Addison,… …   Wikipedia

  • Addison's disease — n a destructive disease marked by deficient adrenocortical secretion and characterized by extreme weakness, loss of weight, low blood pressure, gastrointestinal disturbances, and brownish pigmentation of the skin and mucous membranes * * * a… …   Medical dictionary

  • Addison's disease — Ad di*son s dis*ease [Named from Thomas Addison, M. D., of London, who first described it.] (Med.) A morbid condition causing a peculiar brownish discoloration of the skin, and thought, at one time, to be due to disease of the suprarenal capsules …   The Collaborative International Dictionary of English

  • Addison's disease — [ad′i sənz] n. [after T. Addison (1793 1860), Eng physician who identified it] a disease caused by failure of the adrenal glands: it is characterized by anemia, weakness, low blood pressure, and brownish discoloration of the skin …   English World dictionary

  • Addison —   [ ædɪsn],    1) Joseph, englischer Schriftsteller und Politiker, * Wilston (bei Amesbury, Wiltshire) 1. 5. 1672, ✝ London 17. 6. 1719; schrieb Essays für die Zeitschriften »The Tatler« (1709 11) und »The Guardian« (1713/14) und gab 1711/12 (mit …   Universal-Lexikon

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