immunologic tolerance

immunologic tolerance
an immune response consisting of the development of specific nonreactivity of the lymphoid tissues to a given antigen that in other circumstances can induce cell-mediated or humoral immunity; it results from previous contact with the antigen and has no effect on the response to non–cross-reacting antigens. Tolerance is readily induced by administration of antigen to immunologically immature animals (fetuses, neonates). In adults tolerance may be induced by repeated administration of very large doses of antigen (high-dose or high-zone t.), or of small doses that are below the threshold required for stimulation of an immune response (low-dose or low-zone t.). Tolerance is most readily induced by soluble antigens administered intravenously; immunosuppression also facilitates the induction of tolerance.

Medical dictionary. 2011.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • immunologic inertia — specific depression of immunity in a mother toward the histocompatibility antigens of a fetus, or in a fetus toward those of the mother; it does not include immunologic tolerance …   Medical dictionary

  • tolerance — 1. The ability to endure or be less responsive to a stimulus, especially over a period of continued exposure. 2. The power of resisting the action of a poison or of taking a drug continuously or in large doses without injurious effects. [L.… …   Medical dictionary

  • Immunologic adjuvant — In immunology, an adjuvant is an agent that may stimulate the immune system and increase the response to a vaccine, without having any specific antigenic effect in itself. [ [http://www.cancer.gov/templates/db alpha.aspx?CdrID=43987 Definition of …   Wikipedia

  • adoptive tolerance — immunologic tolerance induced by the passive transfer to an irradiated recipient animal of lymphoid cells from a donor rendered tolerant to an antigen …   Medical dictionary

  • transplantation tolerance — immunologic tolerance of transplanted tissue …   Medical dictionary

  • split tolerance — 1. following induction of 2. immunologic tolerance to allogeneic cells, tolerance to an antigen or group of antigens on the cell surface occurs, while there is an immune response to other antigens on the cell surface. immunologic tolerance that… …   Medical dictionary

  • self tolerance — immunologic unresponsiveness to autoantigens (self antigens), acquired during fetal life by a process of “self recognition.” Theories of tolerance induction include deletion of antigen responsive clones of B cells, antigen induced… …   Medical dictionary

  • Immune tolerance in pregnancy — or gestational/maternal immune tolerance is the absence of a maternal immune response against the fetus and placenta, which thus may be viewed as unusually successful allografts, since they genetically differ from the mother.[1] In the same way,… …   Wikipedia

  • Immune tolerance — or immunological tolerance is the process by which the immune system does not attack an antigen.[1] It can be either natural or self tolerance , in which the body does not mount an immune response to self antigens, or induced tolerance , in which …   Wikipedia

  • high-dose tolerance — high zone tolerance see immunologic t …   Medical dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”