diphtheria toxin
a protein exotoxin produced by virulent (lysogenic) strains of Corynebacterium diphtheriae that is primarily responsible for the pathogenesis of diphtheritic infection. It is an enzyme that inhibits protein synthesis by inactivating a factor (EF-2) required for 2. the transfer of polypeptidyl-tRNA from acceptor to donor sites on ribosomes.

Medical dictionary. 2011.

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  • diphtheria toxin — An AB exotoxin (62 kD) coded by b corynephage of virulent Corynebacterium diphtheriae strains (that can produce a repressor of toxin production). The B subunit binds to receptors on the surface of the target cell and facilitates the entry of the… …   Dictionary of molecular biology

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  • toxin-antitoxin — n a mixture of toxin and antitoxin used esp. formerly in immunizing against a disease (as diphtheria) for which they are specific * * * (TA) tox·in an·ti·tox·in (TA) (tok″sin anґtĭ tok″sin) a nearly neutral mixture of diphtheria… …   Medical dictionary

  • diphtheria — /dif thear ee euh, dip /, n. Pathol. a febrile, infectious disease caused by the bacillus Corynebacterium diphtheriae, and characterized by the formation of a false membrane in the air passages, esp. the throat. [1850 55; < NL < F diphthérie < Gk …   Universalium

  • Toxin — This article is about the class of poisonous substances. For other uses, see Toxin (disambiguation). Universal warning symbol used to indicate toxic substances or environments A toxin (from Ancient Greek: τοξικόν toxikon) is a poisonous… …   Wikipedia

  • diphtheria antitoxin — [USP] equine antitoxin from horses immunized against diphtheria toxin or the toxoid; administered intramuscularly or intravenously in the treatment of suspected cases of diphtheria …   Medical dictionary

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