- A substance found in a plant that is used in clinical medicine for the treatment of gouty arthritis and in the laboratory to arrest cells during cell division (by disrupting the spindle) so their chromosomes can be visualized. The name colchicine is from the Greek kolchikon meaning autumn crocus or
* * *An alkaloid obtained from Colchicum autumnale (family Liliaceae); used in the chronic treatment of gout. Inhibits microtuble formation.
* * *col·chi·cine 'käl-chə-.sēn, 'käl-kə- n a poisonous alkaloid C22H25NO6 that inhibits mitosis, is extracted from the corms or seeds of the autumn crocus, and is used in the treatment of gout and acute attacks of gouty arthritis
* * *n.a drug obtained from the meadow saffron (Colchicum autumnale), used to relieve pain in attacks of gout and in the prevention of attacks of polyserositis. It is administered by mouth; common side-effects are nausea, vomiting, diarrhoea, and stomach pains.
* * *col·chi·cine (kolґchĭ-sēn) [USP] an alkaloid obtained from species of Colchicum, used in the treatment of gouty arthritis and to prevent febrile attacks in familial Mediterranean fever. It binds to microtubules and is used in the laboratory to arrest cell division by disrupting the mitotic spindle. Its action in gout may be due to inhibition of granulocyte migration into areas of inflammation.
Medical dictionary. 2011.