Colchicine
A substance found in a plant that is used in clinical medicine for the treatment of gouty arthritis and in the laboratory to arrest cells during cell division (by disrupting the spindle) so their chromosomes can be visualized. The name colchicine is from the Greek kolchikon meaning autumn crocus or
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An alkaloid obtained from Colchicum autumnale (family Liliaceae); used in the chronic treatment of gout. Inhibits microtuble formation.

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col·chi·cine 'käl-chə-.sēn, 'käl-kə- n a poisonous alkaloid C22H25NO6 that inhibits mitosis, is extracted from the corms or seeds of the autumn crocus, and is used in the treatment of gout and acute attacks of gouty arthritis

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n.
a drug obtained from the meadow saffron (Colchicum autumnale), used to relieve pain in attacks of gout and in the prevention of attacks of polyserositis. It is administered by mouth; common side-effects are nausea, vomiting, diarrhoea, and stomach pains.

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col·chi·cine (kolґchĭ-sēn) [USP] an alkaloid obtained from species of Colchicum, used in the treatment of gouty arthritis and to prevent febrile attacks in familial Mediterranean fever. It binds to microtubules and is used in the laboratory to arrest cell division by disrupting the mitotic spindle. Its action in gout may be due to inhibition of granulocyte migration into areas of inflammation.

Medical dictionary. 2011.

Look at other dictionaries:

  • Colchicine — Systematic (IUPAC) name N ​[(7S …   Wikipedia

  • Colchicine — Structure chimique Général Nom IUPAC N [(7S) 5,6,7,9 tétrahydro 1,2,3,10 tétraméthoxy 9 oxobenzo[a]heptalen 7 yl)acé …   Wikipédia en Français

  • colchicine — [ kɔlʃisin ] n. f. • 1834; de colchique ♦ Pharm. Alcaloïde toxique extrait des graines de colchique, antimitotique, employé à faible dose dans le traitement de la goutte. ● colchicine nom féminin Substance d origine végétale possédant des… …   Encyclopédie Universelle

  • Colchicine — Col chi*cine (? or ?), n. [Cf. F. colchicine.] (Chem.) A powerful vegetable alkaloid, {C17H19NO5}, extracted from the {Colchicum autumnale}, or meadow saffron, as a white or yellowish amorphous powder, with a harsh, bitter taste; called also… …   The Collaborative International Dictionary of English

  • colchicine — colchicine. См. колхицин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • colchicine — [käl′chi sēn΄, käl′chisin΄; käl′kisēn΄, käl′kisin΄] n. [< COLCHICUM + INE3] a poisonous, yellow alkaloid, C22H25NO6, extracted from the seeds or corms of a species of colchicum ( Colchicum autumnale): used in the treatment of gout, in genetic… …   English World dictionary

  • colchicine — /kol cheuh seen , sin, kol keuh /, n. Pharm. a pale yellow, crystalline alkaloid, C22H25NO6, the active principle of colchicum. [1850 55; COLCHIC(UM) + INE2] * * * ▪ chemical compound       drug used in the treatment of gout, a disease that is… …   Universalium

  • colchicine — kolchicinas statusas T sritis augalininkystė apibrėžtis Nuodingas augalinės kilmės alkaloidas, sukeliantis poliploidizaciją dėl mitozės achromatinės verpstės suardymo. atitikmenys: angl. colchicine rus. колхицин …   Žemės ūkio augalų selekcijos ir sėklininkystės terminų žodynas

  • colchicine — noun Date: circa 1847 a poisonous alkaloid C22H25NO6 that inhibits mitosis, is extracted from the corms or seeds of the autumn crocus (Colchicum autumnale), and is used especially in the treatment of gout and to produce polyploidy in plants …   New Collegiate Dictionary

  • colchicine — Alkaloid (400 D) isolated from the Autumn crocus ( Colchicum autumnale ) that blocks microtubule assembly by binding to the tubulin heterodimer (but not to tubulin). As a result of interfering with microtubule reassembly will block mitosis at… …   Dictionary of molecular biology

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