Collagen
Collagen is the principal protein of the skin, tendons, cartilage, bone and connective tissue.
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The major protein (comprising over half of that in mammals) of the white fibers of connective tissue, cartilage, and bone, that is insoluble in water but can be altered to easily digestible, soluble gelatins by boiling in water, dilute acids, or alkalis. It is high in glycyl, l-alanyl, l-prolyl, and l-4-hydroxyprolyl residues, but is low in sulfur and has no l-tryptophanyl residues. It comprises a family of genetically distinct molecules all of which have a unique triple helix configuration of three polypeptide subunits known as α-chains; at least 13 types of c. have been identified, each with a different polypeptide chain. SEE ALSO: c. fiber. SYN: ossein, osseine, ostein, osteine. [G. koila, glue, + -gen, producing]
- type I c. the most abundant c., which forms large well-organized fibrils having high tensile strength.
- type II c. c. unique to cartilage, nucleus pulposis, notochord, and vitreous body; it forms as thin highly glycosylated fibrils.
- type III c. c. characteristic of reticular fibers.
- type IV c. a less distinctly fibrillar form of c. characteristic of basement membranes.

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col·la·gen 'käl-ə-jən n an insoluble fibrous protein of vertebrates that is the chief constituent of the fibrils of connective tissue (as in skin and tendons) and of the organic substance of bones and yields gelatin and glue on prolonged heating with water
col·la·gen·ic .käl-ə-'jen-ik adj
col·lag·e·nous kə-'laj-ə-nəs adj

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n.
a protein that is the principal constituent of white fibrous connective tissue (as occurs in tendons). Collagen is also found in skin, bone, cartilage, and ligaments. It is relatively inelastic but has a high tensile strength.

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col·la·gen (kolґə-jən) [Gr. kolla glue + -gen] any of a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility. At least 25 types exist, each composed of tropocollagen (q.v.) units that share a common triple-helical shape but vary in composition between types, with the types being localized to different tissues, stages, or functions. In some types, including the most common, Type I, the tropocollagen rods associate to form fibrils or fibers; in other types the rods are not fibrillar but are associated with fibrillar collagens, while in others they form nonfibrillar, nonperiodic, but structured networks. Collagen is converted to gelatin by boiling. See also under disease, fiber, and fibril.

Medical dictionary. 2011.

Look at other dictionaries:

  • Collagen — Col la*gen, n. [Gr. ko lla glue + gen.] (Physiol. Chem.) The chemical basis of ordinary connective tissue, as of tendons or sinews and of bone. On being boiled in water it becomes gelatin or glue. [1913 Webster] …   The Collaborative International Dictionary of English

  • collagen — collagen. См. коллаген. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Collagen — Collagen, Glutin (s.d.) gebendes Gewebe …   Pierer's Universal-Lexikon

  • collagen — structural protein of connective tissue, 1843, from Fr. collagène, from Gk. kolla glue + gen giving birth to (see GEN (Cf. gen)) …   Etymology dictionary

  • collagen — ► NOUN ▪ the main structural protein found in animal connective tissue, yielding gelatin when boiled. ORIGIN French collagène, from Greek kolla glue …   English terms dictionary

  • collagen — [käl′ə jən] n. [< Gr kolla, glue + GEN] a fibrous protein found in connective tissue, bone, and cartilage collagenic [käl′əjən′ik] adj. collagenous [kə laj′ə nəs] adj …   English World dictionary

  • Collagen — Tropocollagen triple helix Collagen /ˈkɒlədʒɨn/ is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals.[1] It is the main component of connectiv …   Wikipedia

  • collagen — collagenous /keuh laj euh neuhs/, adj. /kol euh jeuhn/, n. Biochem. any of a class of extracellular proteins abundant in higher animals, esp. in the skin, bone, cartilage, tendon, and teeth, forming strong insoluble fibers and serving as… …   Universalium

  • collagen — [[t]kɒ̱ləʤən[/t]] N UNCOUNT Collagen is a protein that is found in the bodies of people and animals. It is often used as an ingredient in cosmetics or is injected into the face in cosmetic surgery, in order to make the skin look younger. The… …   English dictionary

  • Collagen — Kollagen (internationalisierte Schreibweise Collagen; Betonung auf der letzten Silbe) ist ein nur bei Menschen und Tieren vorkommendes Strukturprotein des Bindegewebes (genauer: der extrazellulären Matrix). Im menschlichen Körper ist Kollagen mit …   Deutsch Wikipedia

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