X-His dipeptidase

X-His dipeptidase
X-His di·pep·ti·dase (di-pepґtĭ-dās) [EC 3.4.13.3] an enzyme of the hydrolase class that catalyzes the cleavage of the dipeptide carnosine into component amino acids β-alanine and histidine; it also acts on some other aminoacyl-L-histidine dipeptides. The tissue isozyme requires zinc ions and does not hydrolyze anserine or homocarnosine; the serum isozyme requires cadmium and does hydrolyze anserine and homocarnosine. Deficiency of the serum isozyme causes serum carnosinase deficiency. Called also carnosinase and aminoacyl-histidine dipeptidase. See also carnosinemia and homocarnosinase.

Medical dictionary. 2011.

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  • aminoacyl-histidine dipeptidase — ami·no·acyl his·ti·dine di·pep·ti·dase (ə me″no aґsəl hisґtĭ dēn di pepґtĭ dās) X His dipeptidase …   Medical dictionary

  • List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia

  • Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français

  • EC 3.4 — Le groupe EC3.4 est un groupe d enzymes appartenant à la famille des hydrolases. Leur rôle est de découper un polypeptide, d où leur nom générique de peptidases. La réaction chimique qu elles catalysent est : AA1 CO NH AA2 + H2O ⇌ AA1 COOH + …   Wikipédia en Français

  • carnosinase — Mammalian enzyme that catalyzes the hydrolysis of carnosine, producing histidine and β alanine; a deficiency of the serum enzyme leads to elevated carnosine levels. * * * car·no·sin·ase (kahrґno sĭ nās″) X His dipeptidase …   Medical dictionary

  • carnosinemia — An autosomal recessive congenital disease, characterized by the presence of excess amounts of carnosine in the blood and urine and caused by a genetic deficiency of the enzyme carnosinase. Clinically c …   Medical dictionary

  • homocarnosinosis — An inborn error in metabolism in which homocarnosine levels are elevated, particularly in the cerebral spinal fluid. * * * ho·mo·car·no·sin·o·sis (ho″mo kahr″no sĭ noґsis) an autosomal recessive aminoacidopathy characterized by… …   Medical dictionary

  • serum carnosinase deficiency — an autosomal recessive aminoacidopathy of carnosine metabolism, due to deficiency of the serum isozyme of X His dipeptidase; it is characterized by urinary excretion of carnosine and accumulation of homocarnosine in the cerebrospinal fluid and… …   Medical dictionary

  • homocarnosinase — ho·mo·car·no·sin·ase (ho″mo kahrґno sĭ nās) former name for an enzyme activity now believed to be part of the serum isozyme of X His dipeptidase (carnosinase) …   Medical dictionary

  • Joseph S. Fruton — Infobox Scientist name = Joseph S. Fruton image width = caption = Joseph S. Fruton birth date = birth date|1912|5|14 birth place = Częstochowa, Poland; residence = nationality = Polish, American, death date = death date and… …   Wikipedia

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