dihydrofolate reductase

dihydrofolate reductase
An enzyme reversibly oxidizing tetrahydrofolate to 7,8-dihydrofolate with NADP+. A crucial enzyme in one-carbon metabolism; used as a marker of drug resistance to methotrexate. SYN: 5,6,7,8-tetrahydrofolate dehydrogenase.

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di·hy·dro·fo·late reductase -'fō-.lāt- n an enzyme that catalyzes the reduction of a folate having one of its rings with two double bonds and two attached hydrogen atoms into the dihydro form differing only in having one double bond and four hydrogen atoms in the same ring, that is essential for DNA and protein synthesis, and that is targeted by some anticancer drugs (as methotrexate) in order to inhibit its positive effect on tumor cell growth and reproduction

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di·hy·dro·fo·late re·duc·tase (di-hi″dro-foґlāt re-dukґtās) [EC 1.5.1.3] an enzyme of the oxidoreductase class that catalyzes the reduction of dihydrofolate to tetrahydrofolate, using NADPH as an electron donor. The reaction produces reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. Deficiency of the enzyme may be a cause of megaloblastic anemia responsive to therapy with reduced forms of folic acid. Abbreviated DHFR.

Medical dictionary. 2011.

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  • Dihydrofolate reductase — Ribbon diagram of human dihydrofolate reductase in complex with folate (blue). From PDB 1DRF …   Wikipedia

  • Dihydrofolate réductase — Structure de la DHFR complexée au folate (à gauche) et au NADPH (à droite) …   Wikipédia en Français

  • dihydrofolate reductase — dihydrofolate reductase. См. дигидрофолатредуктаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Dihydrofolate reductase inhibitor — A dihydrofolate reductase inhibitor is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate. Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to therapeutic… …   Wikipedia

  • dihydrofolate reductase — (= DHFR) An enzyme (EC 1.5.1.3) involved in the biosynthesis of folic acid coenzymes, that transfers hydrogen from NADP to dihydrofolate, yielding tetrahydrofolic acid, an essential vitamin cofactor in purine, thymidine and methionine synthesis.… …   Dictionary of molecular biology

  • dihydrofolate reductase inhibitor — any of various drugs that interfere with the conversion of folic acid to its active form in the body. They include pyrimethamine, trimethoprim, triamterene, and methotrexate. When such drugs are necessary, folate deficiency is treated with… …   Medical dictionary

  • dihydrofolate reductase inhibitor — any of various drugs that interfere with the conversion of folic acid to its active form in the body. They include pyrimethamine, trimethoprim, and methotrexate. When such drugs are necessary, folate deficiency is treated with folinic acid rather …   The new mediacal dictionary

  • Reductase — Réductase Une réductase est une enzyme qui diminue l énergie d activation d une réaction d oxydo réduction. Exemples 5 alpha réductase, enzyme du métabolisme de la testostérone, cytochrome b5 réductase Folate et Dihydrofolate réductase HMG CoA… …   Wikipédia en Français

  • Dihydrofolate — Vitamine B9 Vitamine B9 Structure chimique de la vitamine B9 Général Synonymes acide folique vitamine M fola …   Wikipédia en Français

  • Réductase — Une réductase est une enzyme qui diminue l énergie d activation d une réaction d oxydo réduction. Exemples 5 alpha réductase, enzyme du métabolisme de la testostérone, cytochrome b5 réductase Folate et Dihydrofolate réductase HMG CoA réductase… …   Wikipédia en Français

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