Disease, Cushing
The constellation of symptoms and signs caused by an excess of cortisol hormone. Cushing disease (or syndrome) is an extremely complex hormonal condition that involves many areas of the body. Common symptoms are thinning of the skin, weakness, weight gain, bruising, hypertension, diabetes, thin weak bones (osteoporosis), facial puffiness and, in women, cessation of menstrual periods. Ironically, one of the commonest causes of Cushing syndrome is the administration of "cortisol-like medications" for the treatment of diverse diseases. All other cases of Cushing syndrome are due to the excess production of cortisol by the adrenal gland as, for example, due to: {{}}An abnormal growth of the pituitary gland, which can stimulate the adrenal gland; A benign or malignant growth within the adrenal gland itself, which produces cortisol; or Production within another part of the body (ectopic production) of a hormone that directly or indirectly stimulates the adrenal gland to make cortisol. The neurosurgeon Harvey Cushing (1869-1939) described excessive production of cortisol by the adrenal gland due specifically to an ACTH-secreting pituitary adenoma, a benign pituitary tumor that puts out ACTH (AdrenoCorticoTropic Hormone). This drives the adrenal gland to overproduce cortisol.

Medical dictionary. 2011.

Look at other dictionaries:

  • Cushing's syndrome — Classification and external resources ICD 10 E24 ICD 9 255.0 …   Wikipedia

  • Cushing ulcer — Classification and external resources DiseasesDB 3259 A Cushing ulcer is a gastric ulcer produced by elevated intracranial pressure. It is also called von Rokitansky Cushing syndrome. Apart from in the stomach, it may also develop in the proximal …   Wikipedia

  • Cushing's disease — Classification and external resources ICD 10 E24.0 Cushing s disease is a cause of Cushing s Syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary. This is most often as a result of a… …   Wikipedia

  • Cushing reflex — (also referred to as the vasopressor response, the Cushing effect, the Cushing reaction, the Cushing phenomenon, the Cushing response, or Cushing s Law) is a physiological nervous system response to increased intracranial pressure (ICP) that… …   Wikipedia

  • Cushing's triad — is a clinical triad variably defined as either hypertension, bradycardia, and irregular respiration [1], or less commonly as widened pulse pressure (with elevated systolic and a either elevated or normal diastolic BP), irregular respiration, and… …   Wikipedia

  • Cushing's disease — [koosh′iŋz] n. [after CUSHING Harvey (Williams)] a disorder of the adrenal cortex caused by a tumor in the pituitary, characterized by obesity, hypertension, diabetes mellitus, etc …   English World dictionary

  • Cushing's syndrome — n an abnormal bodily condition that is caused by excess corticosteroids and esp. cortisol usu. from adrenal or pituitary hyperfunction and that is characterized by a variety of signs and symptoms including esp. a change in appearance marked by… …   Medical dictionary

  • Cushing syndrome — Disorder named for Harvey Williams Cushing, caused by adrenal cortex overactivity. If caused by a pituitary gland tumour, it is called Cushing disease. Symptoms include obesity of the trunk and face ( moon face ), muscle wasting, high blood… …   Universalium

  • Cushing syndrome — The constellation of symptoms and signs caused by an excess of cortisol hormone. Cushing syndrome is an extremely complex hormonal condition that involves many areas of the body. Common symptoms are thinning of the skin, weakness, weight gain,… …   Medical dictionary

  • Cushing disease response (phenomenon reflex) etc. — Cush·ing disease, response (phenomenon, reflex), etc. (kooshґing) [Harvey Williams Cushing, American surgeon, 1869–1939] see under disease, response, syndrome, and ulcer. See also equine Cushing disease, under disease …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”