folinic acid
1. The active form of folic acid that acts as a formyl group carrier in transformylation reactions; the calcium salt, leucovorin calcium, has therapeutic use. 2. The term is occasionally applied to other folates. SYN: citrovorum factor, leucovorin.

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fo·lin·ic acid fō-'lin-ik- n LEUCOVORIN

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a derivative of folic acid involved in purine synthesis. Administered by mouth or by injection in the form of its calcium salts, it is used to reverse the biological effects of methotrexate and other dihydrofolate reductase inhibitor and so to prevent excessive toxicity. This action is termed folinic acid rescue. Folinic acid has a potentiating effect with fluorouracil, with which it is often used. Trade names: Isovorin, Lederfolin, Refolinon.

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fo·lin·ic ac·id (fo-linґik) the 5-formyl derivative of tetrahydrofolic acid; it can act as a coenzyme carrier in certain folate-mediated reactions but does not require dihydrofolate reductase activity and thus it is used, as the calcium salt leucovorin calcium, in treating some disorders of folic acid deficiency. Called also leucovorin and citrovorum factor.

Medical dictionary. 2011.

Look at other dictionaries:

  • Folinic acid — Systematic (IUPAC) name (2S) 2 {[4 [(2 amino 5 formyl 4 oxo 5,6,7,8 tetrahydro 1H pteridin 6 yl)methylamino] benzoyl]amino}pentanedioic acid Clinical data …   Wikipedia

  • folinic acid — [fō lin′ik] n. [ FOL(IC ACID) + IN1 + IC] the active substance, C20H23N7O7, into which folic acid is converted in body tissue …   English World dictionary

  • folinic acid — a derivative of folic acid involved in purine synthesis. Administered by mouth or by injection in the form of its calcium or disodium salts, it is used to reverse the biological effects of methotrexate and other dihydrofolate reductase inhibitors …   The new mediacal dictionary

  • folinic acid — (Biochemistry) citrovorum factor, derivative of folic acid (used to treat anemia resulting from a folic acid deficiency), active metabolite of folic acid …   English contemporary dictionary

  • folinic acid — fōˈlinik noun Etymology: folic + in + ic : any of several natural or synthetic acids (as leucovorin) that are metabolically active forms of folic acid and support the growth of certain bacteria (as Leuconostoc citrovorum) called also citrovorum… …   Useful english dictionary

  • folinic acid — /foh lin ik/, Biochem., Pharm. a crystalline, slightly water soluble solid, C20H23N7O7, produced by fermentation or derived from folic acid, used in medicine in the treatment of certain anemias. [1945 50; FOL(IC) + IN2 + IC] * * * …   Universalium

  • folinic acid — noun A particular drug used in the treatment of cancer. Syn: leucovorin …   Wiktionary

  • folinic acid-SF — noun see leucovorin …   Useful english dictionary

  • Кислота Фолиновая (Folinic Acid) — производная фолиевой кислоты, участвующая в синтезе пурина. Назначается внутрь или в инъекциях; применяется для получения эффектов, обратных биологическому действию метотрексата и других ингибиторов дигидрофолата редуктазы, а также для… …   Медицинские термины

  • Folic acid — Folic acid …   Wikipedia

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