fumarate hydratase

fumarate hydratase
An enzyme catalyzing the reversible interconversion of fumarate and water to malate, a reaction of importance in the tricarboxylic acid cycle. A deficiency will lead to mental retardation. SYN: fumarase.

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fu·ma·rate hy·dra·tase (fuґmə-rāt hiґdrə-tās) [EC 4.2.1.2] an enzyme of the lyase class that catalyzes the hydration of fumarate to form L-malate in a reaction of the tricarboxylic acid cycle (see illustration under cycle). Deficiency causes mental retardation and failure to thrive. Called also fumarase.

Medical dictionary. 2011.

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