gammopathy

gammopathy
- benign monoclonal g. SYN: monoclonal g. of undetermined significance.
- biclonal g. a g. in which the serum contains two distinct monoclonal immunoglobulins.
- monoclonal g. any one of a group of disorders due to proliferation of a single clone of lymphoid or plasma cells and characterized by the presence of monoclonal immunoglobulin in serum or urine (visible on electrophoresis as a single peak).
- monoclonal g. of undetermined significance a paraproteinemia (an abnormal gammaglobulin, typically with λ light chain component) of less than 3 g/100 ml, which at the time of discovery, is without apparent cause; specifically, there is no evidence of multiple myeloma or other malignant disorders. SYN: benign monoclonal g..
- monoclonal g. of unknown significance (MGUS) a g. diagnosed by electrophoresis of serum of asymptomatic elderly persons who have no other evidence of plasma cell neoplasia; in 20% of cases it evolves into plasma cell malignancy.
- polyclonal g. a g. in which there is a heterogeneous increase in immunoglobulins involving more than one cell line; may be caused by any of a variety of inflammatory, infectious, or neoplastic disorders.

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gam·mop·a·thy gam-'äp-ə-thē n, pl -thies a disorder characterized by a disturbance in the body's synthesis of antibodies <multiple myeloma is a type of monoclonal \gammopathy>

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gam·mop·a·thy (gam-opґə-the) [gamma globulin + -pathy] a condition marked by disturbed immunoglobulin synthesis.

Medical dictionary. 2011.

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  • gammopathy — /ga mop euh thee/, n. Immunol. a disorder of the immune system characterized by abnormally increased levels of immunoglobulins in the blood. [GAMM(A GLOBULIN) + O + PATHY] * * * …   Universalium

  • gammopathy — noun Any disease or malfunction that affects the production of gamma globulin and related immunoglobulins Syn: gammaglobulinopathy …   Wiktionary

  • gammopathy — noun a disturbance in the synthesis of immunoglobulins; proteins having antibody activity increase greatly in the blood • Hypernyms: ↑pathology * * * /ga mop euh thee/, n. Immunol. a disorder of the immune system characterized by abnormally… …   Useful english dictionary

  • Monoclonal gammopathy of undetermined significance — Classification and external resources Schematic representation of a normal protein electrophoresis gel. A small spike would be present in the gamma (γ) band in MGUS ICD 1 …   Wikipedia

  • Monoclonal gammopathy — Classification and external resources ICD O: M9765/1 Monoclonal gammopathy is a synonym for paraproteinemia …   Wikipedia

  • monoclonal gammopathy — n any of various disorders marked by proliferation of a single clone of antibody producing lymphoid cells resulting in an abnormal increase of a monoclonal antibody in the blood serum and urine and that include both benign or asymptomatic… …   Medical dictionary

  • benign monoclonal gammopathy — the presence of a serum M component without signs or symptoms of multiple myeloma, Waldenstrцm macroglobulinemia, or other plasma cell neoplasms; it occurs in about 3 per cent of the population over age 70. A few patients eventually develop a… …   Medical dictionary

  • monoclonal gammopathy of undetermined significance — (MGUS) benign monoclonal g …   Medical dictionary

  • monoclonal gammopathy of undetermined significance — MGUS. A benign condition in which there is a high level of a protein called M protein in the blood. Patients with MGUS are at an increased risk of developing cancer. Also called MGUS …   English dictionary of cancer terms

  • MGUS — Abbreviation for monoclonal gammopathy of unknown significance. * * * monoclonal gammopathies of undetermined significance * * * monoclonal gammopathy of undetermined significance; see benign monoclonal gammopathy, under gammopathy …   Medical dictionary

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