Endostatin

Endostatin
Endostatin is a piece (a fragment) of a protein, collagen 18, found in all blood vessels. This fragment is normally secreted by tumors. It appears to halt the process of developing new blood vessels (angiogenesis) which is necessary to tumor development. Endostatin may, it is hoped, represent a prototype for a new class of agents with which to treat cancer.

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en·do·stat·in .en-də-'stat-ən n a polypeptide that is a proteolytic fragment of the carboxyl terminus of a collagen found esp. in the epithelial basement membrane and that inhibits angiogenesis, tumor growth, and endothelial cell proliferation

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n.

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en·do·stat·in (en″do-statґin) a protein produced in the body by proteolysis of collagen XVIII at its carboxyl terminal; it inhibits angiogenesis and tumor growth and is under study as an antineoplastic.

Medical dictionary. 2011.

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Look at other dictionaries:

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  • endostatin — en·do·stat·in (ĕn dō stătʹn) n. A potent, naturally occurring antiangiogenic protein that inhibits the formation of the blood vessels that feed tumors. It is under investigation as a potential cancer therapy.   [endothelial + stat + in.] * * * …   Universalium

  • endostatin — noun A protein which inhibits the formation of the blood vessels that supply tumours …   Wiktionary

  • endostatin — /ɛndoʊˈsteɪtən/ (say endoh staytuhn) noun a naturally occurring protein that inhibits the growth of blood vessels, used in the treatment of some cancers to starve malignant tumours and prevent their growth. {endo + stat + in1} …  

  • Endostatin — Endostatˈin® noun An angiogenesis inhibiting drug, used in experimental treatments to inhibit the growth of cancerous tumours • • • Main Entry: ↑endo …   Useful english dictionary

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  • Collagen, type XVIII, alpha 1 — PDB rendering based on 1bnl …   Wikipedia

  • COL18A1 — Collagen, type XVIII, alpha 1, also known as COL18A1, is a human gene. PBB Summary section title = summary text = This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins… …   Wikipedia

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