idiotype

idiotype
Collection of idiotopes within the variable region that confers on an immunoglobulin molecule an antigenic “individuality” and is frequently a unique attribute of a given antibody in a given animal. It is the product of a limited number of B lymphocyte clones; also found on the T-cell receptor. See idiotope. [idio- + G. typos, model]

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id·io·type 'id-ē-ə-.tīp n the molecular structure and conformation in the variable region of an immunoglobulin that confers its antigenic specificity compare ALLOTYPE, ISOTYPE
id·io·typ·ic .id-ē-ə-'tip-ik adj

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id·io·type (idґe-o-tīpґ) a set of one or more idiotopes that distinguish a clone of immunoglobulin-producing cells from other clones. Idiotypes occur in the variable domains of immunoglobulin molecules and may be within, near to, or outside of the antigen-binding site; antibodies to idiotypes located within or near to the antigen-binding site will prevent the immunoglobulin from combining with antigen. idiotypic adj

Medical dictionary. 2011.

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  • idiotype — idiotype. См. идиотип. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Idiotype — In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The variable region of antigen …   Wikipedia

  • Idiotype — L idiotype, du grec particulier, forme , est une caractéristique retrouvée chez de rares individus d une même espèce. Cette notion a été développée, par Jacques Oudin (biologiste) en particulier, lors de l étude des spécificités antigéniques des… …   Wikipédia en Français

  • idiotype — The antigenic specificities defined by the unique sequences (idiotopes) of the antigen combining site. Thus anti idiotype antibodies combine with those specific sequences, may block immunological reactions, and may resemble the epitope to which… …   Dictionary of molecular biology

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  • idiotype — An identifying property or characteristic of an item or system. 1.A plant form expected on physiological grounds to represent an optimal type for the environment in which the plant is to be grown. 2. A classification of antibody molecules… …   Glossary of Biotechnology

  • idiotype — noun Date: 1960 the molecular structure and conformation of an antibody that confers its antigenic specificity • idiotypic adjective …   New Collegiate Dictionary

  • idiotype — ideotype …   Dictionary of ichthyology

  • idiotype — n. [Gr. idios, personal; typos, type] Genotype; idioplasm …   Dictionary of invertebrate zoology

  • idiotype — (id e o taīp ) A set of one or more unique epitopes in the variable region of an immunoglobulin that distinguishes it from immunoglobulins produced by different plasma cells …   Dictionary of microbiology

  • idiotype — idiotypic /id ee euh tip ik/, adj. idiotypy /id ee euh tuy pee/, n. /id ee euh tuyp /, n. Immunol. the molecular arrangement of amino acids unique to the antigen binding site of a particular antibody. [1969; back formation from idiotypic or… …   Universalium

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