Estrogen-associated blood clots
Blood clots are occasional but serious side effects of estrogen therapy. They are dose-related, that is, they occur more frequently with higher doses of estrogen. Estrogen therapy preparations (all of which carry this risk) include: esterified estrogens esterified estrogens and methyltestosterone estradiol estrogens (conjugated) and medroxyprogesterone estrogens conjugated The brand names of the estrogen therapy preparations carrying this risk include: CLIMARA (estradiol) ESTRACE (estradiol) ESTRADERM (estradiol) ESTRATAB (esterified estrogens) ESTRATEST (esterified estrogens and methyltestosterone ) MENEST (esterified estrogens) OGEN (estropipate) PREMARIN (estrogens conjugated) PREMPHASE (estrogens conjugated and medroxyprogesterone) PREMPRO (estrogens conjugated and medroxyprogesterone) Cigarette smokers on estrogen therapy are at a higher risk than non-smokers for blood clots. Therefore, patients requiring estrogen therapy are strongly encouraged to quit smoking.

Medical dictionary. 2011.

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