Exonuclease
An enzyme that cleaves nucleotide bases sequentially from the free ends of a nucleic acid (DNA or RNA).
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A nuclease that releases one nucleotide at a time, serially, beginning at one end of a polynucleotide (nucleic acid); several have been prepared from Escherichia coli, designated e. I, e. II, etc.; e. III, which removes nucleotides from 3′ ends of DNA, is used in DNA sequencing. Cf.:endonuclease.

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exo·nu·cle·ase .ek-sō-'n(y)ü-klē-.ās, -.āz n an enzyme that breaks down a nucleic acid by removing nucleotides one by one from the end of a chain compare ENDONUCLEASE

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exo·nu·cle·ase (ek″so-nooґkle-ās) [EC 3.1.11–16] any nuclease specifically catalyzing the hydrolysis of terminal bonds of deoxyribonucleotide or ribonucleotide chains, releasing mononucleotides. Cf. endonuclease.

Medical dictionary. 2011.

Look at other dictionaries:

  • Exonuclease — Exonucléase L exonucléase est une nucléase, une enzyme qui coupe les acide nucléiques (ADN ou ARN). Le suffixe exo précise que cette coupure se fait à partir d une extrémité[1], un nucléotide à la fois, et dans un sens 5 vers 3 ou l inverse. Par… …   Wikipédia en Français

  • exonuclease — exonuclease. См. экзонуклеаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Exonuclease — Exonucleases are enzymes (found as individual enzymes, or as parts of larger enzyme complexes) that cleave nucleotides one at a time from an end of a polynucleotide chain. These enzymes hydrolyze phosphodiester bonds from either the 3 or 5… …   Wikipedia

  • Exonucléase — L exonucléase est une nucléase, une enzyme qui coupe les acide nucléiques (ADN ou ARN). Le préfixe exo précise que cette coupure se fait à partir d une extrémité[1], un nucléotide à la fois, et dans un sens 5 vers 3 ou l inverse. Par exemple, l… …   Wikipédia en Français

  • exonuclease — Enzyme that digests the ends of a piece of DNA (cf. endonuclease). The nature of the digestion is usually specified (eg. 5&’ or 3&’ exonuclease) …   Dictionary of molecular biology

  • exonuclease — egzonukleazė statusas T sritis chemija apibrėžtis Nukleazė, katalizuojanti fosfodiesterinių ryšių hidrolizę nuo polinukleotidinės grandinės 5′ arba 3′ galinio nukleotido. atitikmenys: angl. exonuclease rus. экзонуклеаза …   Chemijos terminų aiškinamasis žodynas

  • exonuclease — noun Date: 1963 an enzyme that breaks down a nucleic acid by removing nucleotides one by one from the end of a chain compare endonuclease …   New Collegiate Dictionary

  • Exonuclease — Als Exonuklease wird eine Nuklease bezeichnet, die von ihrem Substrat (DNA und/oder RNA) pro Reaktionszyklus jeweils ein Nukleinsäuremonomer vom Ende des Moleküls her abspaltet. Durch aufeinanderfolgende Reaktionen kommt es zum teilweisen oder… …   Deutsch Wikipedia

  • exonuclease — ex·o·nu·cle·ase (ĕk sō no͞oʹklē ās , āz , nyo͞oʹ ) n. Any of a group of enzymes that catalyze the hydrolysis of single nucleotides from the end of a DNA or RNA chain. * * * …   Universalium

  • exonuclease — noun Any of a group of enzymes which cleave single nucleotides from the end of a polynucleotide (DNA or RNA) chain …   Wiktionary

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