Favism
A condition characterized by hemolytic anemia (breakup of red blood cells) after eating fava beans (Vicia fava) or being exposed to the pollen of the fava plant. This dangerous reaction occurs exclusively in people with a deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD), an X-linked genetic trait. However, not all G6PD-deficient families appear at risk for favism, indicating the additional need for a single autosomal (not X-linked) gene to create the susceptibility to favism of G6PD-deficient persons. The active hemolytic principle in fava beans is > likely DOPA-quinone. Differences in susceptibility to favism may be related to differences in the enzymatic system that converts L-DOPA to DOPA-quinone.
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An acute condition seen chiefly in Italy, following the ingestion of certain species of beans, e.g., Vicia faba, or inhalation of the pollen of its flower; characterized by fever, headache, abdominal pain, severe anemia, prostration, and coma; it occurs in certain individuals with genetic erythrocytic deficiency of glucose 6-phosphate dehydrogenase. Chance exposure to the Vicia faba, by its impact on the phenotype of glucose-6-phosphate dehydrogenase, impinges on the expression or the gene, an example of incomplete penetrance. SYN: fabism. [Ital. favismo, from fava, bean]

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fa·vism 'fä-.viz-əm, 'fā- n a condition esp. of males of Mediterranean descent that is marked by the development of hemolytic anemia upon consumption of broad beans or inhalation of broad bean pollen and is caused by a usu. inherited deficiency of glucose-6-phosphate

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n.
an inherited defect in the enzyme glucose-6-phosphate dehydrogenase causing the red blood cells to become sensitive to a chemical in broad beans. It results in destruction of red blood cells (haemolysis), which may lead to severe anaemia, requiring blood transfusion. Favism occurs in parts of the Mediterranean and Iran. See also glucose-6-phosphate dehydrogenase deficiency.

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fa·vism (faґvis-əm) [Italian fava bean] an acute hemolytic anemia caused by ingestion of fava beans or inhalation of the pollen of the plant Vicia faba (fava), occurring in susceptible individuals usually as a result of a hereditary deficiency of glucose-6-phosphate dehydrogenase in erythrocytes; see glucose-6-phosphate dehydrogenase deficiency.

Medical dictionary. 2011.

Look at other dictionaries:

  • favism — FAVÍSM s.n. (med.) Anemie hemolitică provocată prin administrarea de sulfamide sau după ingerarea (ingera) boabelor unei plante potagere (potager). [< fr. favisme]. Trimis de LauraGellner, 13.09.2007. Sursa: DN  FAVÍSM s. n. anemie hemolitică …   Dicționar Român

  • favism — favism. См. фавизм. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • favism — [fä′viz΄əm, fā′viz΄əm] n. an acute anemia in certain people, caused by their reaction to the fava bean or its pollen …   English World dictionary

  • favism — /fah viz euhm/, n. Pathol. acute hemolytic anemia caused by ingestion or inhalation of fava bean pollen. [1900 05; < It favismo, equiv. to fav(a) bean + ismo ISM] * * * ▪ genetic disorder       a hereditary disorder involving an allergic like… …   Universalium

  • favism — n. an inherited defect in the enzyme glucose 6 phosphate dehydrogenase causing the red blood cells to become sensitive to a chemical in broad beans. It results in destruction of red blood cells (haemolysis), which may lead to severe anaemia,… …   The new mediacal dictionary

  • favism — noun Date: circa 1927 a condition especially of males of Mediterranean descent that is marked by the development of hemolytic anemia upon consumption of broad beans or inhalation of broad bean pollen and is caused by a usually inherited… …   New Collegiate Dictionary

  • Favism — Haemolytic anaemia induced in individuals who are glucose 6 phosphate dehydrogenase deficient by eating fava beans (from Vicia fava ) …   Dictionary of molecular biology

  • favism — disease, caused by enzyme deficiency in some people, that destroys red blood cells when fava beans are eaten …   Eponyms, nicknames, and geographical games

  • favism — n. disease caused by inhaling the pollen of the fava bean …   English contemporary dictionary

  • favism — fa·vism …   English syllables

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