ligation

1. Application of a ligature. 2. The act of binding or annealing. [L. ligatio, fr. ligo, to bind]

- blunt-end l. a reaction that joins two DNA duplexes directly at their blunt ends.

- enzyme-catalyzed l. an enzyme-mediated joining of phosphodiester linkage of two stretches of DNA or RNA, or of peptide linkage of two polypeptides.

- pole l. a l. at the root of an organ to shut off or diminish blood supply.

- surgical l. in dentistry, the surgical exposure of an unerupted tooth so that a metal ligature can be placed around its cervix and fastened to an orthodontic appliance to facilitate eruption.

- tooth l. the binding together of teeth with wire for stabilization and immobilization following traumatic injury or orthognathic surgery, or during periodontal therapy.

- tubal l. interruption of the continuity of the oviducts by cutting, cautery, or by a plastic or metal device to prevent future conception.

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li·ga·tion lī-'gā-shən n

1 a) the surgical process of tying up an anatomical channel (as a blood vessel)

b) the process of joining together chemical chains (as of DNA or protein)

2) something that binds: LIGATURE

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n.

the application of a ligature.

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li·ga·tion (li-gaґshən) [L. ligatio] 1. the application of a ligature. 2. the process of annealing or joining, such as the DNA ligase–catalyzed joining of two DNA fragments to form a recombinant molecule.