Ferritin
The major iron storage protein. The blood level of ferritin serves as an indicator of the amount of iron stored in the body. Ferritin has the shape of a hollow sphere that permits the entry of a variable amount of iron for storage (as ferric hydroxide phosphate complexes). Liver and spleen ferritin consists of 24 subunits of 2 kinds, the heavy and the light subunit. The genes that encode the light and heavy chains are on different chromosomes. The light chain genes are in chromosome region 19q13.3-q13.4 while those for the heavy chain are in chromosome region 11q12-q13. Mutations in the ferritin light chain are responsible for a disease called the hyperferritinemia-cataract syndrome characterized by cataracts (opacities in the lens of the eye) and high levels of ferritin in the blood.
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An iron-protein complex, containing up to 23% iron, formed by the union of ferric ions with apoferritin; it is found in the intestinal mucosa, spleen, bone marrow, reticulocytes, and liver, and regulates iron storage and transport from the intestinal lumen to plasma.

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fer·ri·tin 'fer-ət-ən n a crystalline iron-containing protein that functions in the storage of iron and is found esp. in the liver and spleen compare HEMOSIDERIN

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n.
an iron-protein complex that is one of the forms in which iron is stored in the tissues.

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fer·ri·tin (ferґĭ-tin) the iron-apoferritin complex, one of the chief forms in which iron is stored in the body; it occurs at least in the gastrointestinal mucosa, liver, spleen, bone marrow, and reticuloendothelial cells generally. See also immunoferritin.

Medical dictionary. 2011.

Look at other dictionaries:

  • Ferritin — Oberflächenmodell des Maus Ferritins (eine einzelne Untereinheit ist violett hervorgehoben) nach PDB  …   Deutsch Wikipedia

  • ferritin — ferritin. См. ферритин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • ferritin — [fer′i tin] n. an iron storing protein found in certain body tissue …   English World dictionary

  • Ferritin — protein Name = ferritin, light polypeptide caption = Structure of the ferritin complex width = 200 HGNCid = 3999 Symbol = FTL AltSymbols = EntrezGene = 2512 OMIM = 134790 RefSeq = NM 000146 UniProt = P02792 PDB = ECnumber = Chromosome = 19 Arm =… …   Wikipedia

  • Ferritin — Fer|ri|tin 〈n. 11; Biochem.〉 ein aus 24 Untereinheiten aufgebautes Protein, das bis zu 4500 Eisenatome speichern kann, ein wichtiges Bindeglied im Eisenstoffwechsel, bes. bei der Bildung der roten Blutkörperchen * * * Fer|ri|tin [↑ Ferri ], das;… …   Universal-Lexikon

  • ferritin — feritinas statusas T sritis chemija apibrėžtis Baltymas, kurio sudėtyje yra Fe³⁺. atitikmenys: angl. ferritin rus. ферритин …   Chemijos terminų aiškinamasis žodynas

  • ferritin — noun Etymology: International Scientific Vocabulary, alteration of ferratin, iron containing protein, from Latin ferratus bound with iron (from ferrum) + International Scientific Vocabulary in Date: 1937 a crystalline iron containing protein that …   New Collegiate Dictionary

  • ferritin — An iron storage protein of mammals, found in liver, spleen, and bone marrow. Morphologically a shell of apoferritin (protein) with a core of ferrous hydroxide/phosphate. It is much used as an electron dense label in electron microscopy …   Dictionary of molecular biology

  • ferritin — /fer i tn/, n. Biochem. an amber colored, crystalline protein, found in the liver, spleen, and bone marrow, that consists of apoferritin combined with a ferric hydroxide ferric phosphate complex and that stores iron for use in metabolism. [1935… …   Universalium

  • ferritin — noun Any of a family of iron carrying globular protein complexes consisting of 24 protein subunits …   Wiktionary

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