Fragile site
A term devised in 1969 by Frederick Hecht to denote a heritable point on a chromosome where gaps and breaks tend to occur.

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a nonstaining gap in the chromatin of a metaphase chromosome, usually in both chromatids, and inherited in a mendelian fashion; the chromosome is easily breakable at this site. In cultured human cells, fragile sites are expressed under conditions of folate or thymidine deprivation or in the presence of methotrexate.

Medical dictionary. 2011.

Look at other dictionaries:

  • fragile site — fragile site. См. ломкий сайт. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Chromosomal fragile site — Silencing of the FMR1 gene in Fragile X syndrome. FMR1 co localizes with a rare fragile site, visible here as a gap on the long arms of the X chromosome. A chromosomal fragile site is a specific heritable point on a chromosome that tends to form… …   Wikipedia

  • heritable fragile site — heritable fragile site. = rare fragile site (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • common fragile site — common fragile site. См. обычный ломкий сайт. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • rare fragile site — rare fragile site. См. редкий ломкий сайт. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • heritable fragile site — heritable fragile site. См. редкий ломкий сайт. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Fragile X syndrome — Classification and external resources Location of FMR1 gene ICD 10 Q99.2 …   Wikipedia

  • Fragile X syndrome — One of the most common causes of inherited mental retardation and neuropsychiatric disease in human beings, affects as many as one in 2000 males and one in 4000 females. The syndrome is also known as FRAXA (the fragile X chromosome itself) and as …   Medical dictionary

  • Fragile sites — There are two kinds of fragile sites: common and rare fragile sites. Rare fragile sites are found in less than 5% of the population and are composed of tri or dinucleotide repeats that may cause spontaneous breaks during replication, frequently… …   Wikipedia

  • fragile-X syndrome — ▪ chromosomal disorder       a chromosomal disorder associated with a fragile site on the end of the X chromosome. The major symptom of the syndrome is diminished mental ability, which may range from mild learning impairment to severe… …   Universalium

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