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mouse

Translation
mouse
A small rodent belonging to the genus Mus.
- joint mice Small fibrous, cartilaginous, or bony loose bodies in the synovial cavity of a joint.
- knockout m. a m. from whose genome a single gene has been artificially deleted.Experimental animals lacking specific genes have become valuable research tools in many branches of medicine, including genetics, physiology, pharmacology, immunology, cell biology, and oncology. A transgenic animal is one into whose genome a foreign gene, constructed by recombinant DNA technology, has been deliberately inserted. Placement of the inserted gene at a specific locus in the genome is made possible by incorporating it in a vector in which it is flanked by DNA sequences unique to the target site. The artificial genetic material is introduced into an embryo, which then develops into a chimera whose tissues contain both normal cells and cells containing the transgene. Matings among such animals yield some offspring that are homozygous for the transgene. If the inserted gene is a nonfunctional (null) allele, it deletes or “knocks out” the normal, wild allele. Not only is the deleted gene not expressed, but the offspring of matings among homozygous individuals constitute a pure strain, all of whose members lack the gene. Although theoretically any animal could be subjected to the knockout technique, mice have been used almost exclusively. Mice are small and easily maintained, and they reproduce rapidly and have a short life span. In addition, m. and human genomes are strikingly similar, with about 75% correspondence of genes. The fact that knockout mice lacking a wide variety of genes are often phenotypically normal indicates that the m. genome, like that of human beings, often has sufficient redundancy to compensate for a single missing pair of alleles. Knockout mice lacking the p53 tumor suppressor gene are used in studies of carcinogenesis, while those lacking the gene for the LDL receptor constitute an animal model of human familial hypercholesterolemia. Knockout mice have proved valuable in revealing the functions of genes for which mutant strains were not previously available.
- multimammate m. an African rodent, Praomys natalensis, widely used in cancer research.
- New Zealand mice inbred strains of mice, either black (NZB) or white (NZW), unique among strains used in experimental immunology because of their proclivity to spontaneous immunologic abnormalities and disorders including systemic lupus erythematosus similar to that found in humans.
- nude m. a hairless mutant m. with thymic hypoplasia, lacking T cells.
- transgenic mice (tranz′jen-ik) Mice that have a piece of foreign DNA integrated into their genome.

Medical dictionary. 2011.

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  • Mouse — (mous), n.; pl. {Mice} (m[imac]s). [OE. mous, mus, AS. m[=u]s, pl. m[=y]s; akin to D. muis, G. maus, OHG. & Icel. m[=u]s, Dan. muus, Sw. mus, Russ. muishe, L. mus, Gr. my^s, Skr. m[=u]sh mouse, mush to steal. [root]277. Cf. {Muscle}, {Musk}.] 1.… …   The Collaborative International Dictionary of English

  • Mouse — Saltar a navegación, búsqueda Un ejemplo de ratón o mouse, con cable y rueda …   Wikipedia Español

  • mouse — 1> зоол. мышь (Mus musculus) Ex: field mouse полевая мышь Ex: little mouse мышонок 2> ласк. мышка, мышонок (о женщине или девушке) Ex: a little mouse of a thing (of a girl) мышонок, мышка (о девочке) 3> робкий, боязливый человек 4> мор. мусинг 5> …   Новый большой англо-русский словарь

  • MOUSE — was founded in 1997 by entrepreneur Andrew Rasiej and Founding Executive Director Sarah Holloway. Along with leaders from the high tech community in New York City, MOUSE spearheaded the process of wiring public schools for Internet access in New… …   Wikipedia

  • Mouse — Mouse, v. t. 1. To tear, as a cat devours a mouse. [Obs.] [Death] mousing the flesh of men. Shak. [1913 Webster] 2. (Naut.) To furnish with a mouse; to secure by means of a mousing. See {Mouse}, n., 2. [1913 Webster] …   The Collaborative International Dictionary of English

  • mouse — 1. noun; pl. mice 1) мышь 2) sl. подбитый глаз 2. v. 1) ловить мышей2) выискивать, выслеживать (тж. mouse around,mouse about, mouse along) mouseout …   Англо-русский словарь Мюллера

  • Mouse — steht für: die englische Bezeichnung für ein Computereingabegerät, siehe Maus (Computer) eine Manga Serie, siehe Mouse (Manga) eine Programmiersprache, siehe Mouse (Programmiersprache) ein US amerikanischer Produzent, siehe Mouse (Produzent) ein… …   Deutsch Wikipedia

  • MOUSE — (jap. マウス mausu) ist eine japanische Manga Serie von Satoru Akahori (Story) und Hiroshi Itaba (Zeichnungen), die auch als Anime umgesetzt wurde. Sie lässt sich dem Seinen Genre zuordnen und hat erotische Inhalte wie Fanservice und Hardcore BDSM… …   Deutsch Wikipedia

  • Mouse — Mouse, v. i. [imp. & p. p. {Moused}; p. pr. & vb. n. {Mousing}.] 1. To watch for and catch mice. [1913 Webster] 2. To watch for or pursue anything in a sly manner; to pry about, on the lookout for something. [1913 Webster] …   The Collaborative International Dictionary of English

  • mouse — mouse. См. mice. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • mouse — mouse. См. мыши. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

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