Granulocytopenia
A marked decrease in the number of granulocytes. Granulocytes are a type of white blood cell filled with microscopic granules that are little sacs containing enzymes that digest microorganisms. Granulocytes are part of the innate, somewhat non specific infection-fighting immune system. They do not respond exclusively to specific antigens, as do B-cells and T-cells. Granulocytopenia or, as it is also called, agranulocytosis results in a syndrome of frequent chronic bacterial infections of the skin, lungs, throat etc. Although "agranulocytosis" literally means no granulocytes, there may, in fact, be some granulocytes but too few of them, i.e. granulocytopenia. Granulocytopenia can be genetic and inherited or it can be acquired as, for example, an aspect of leukemia. Neutrophils, eosinophils and basophils are all types of granulocytes. They are named by the staining features of their granules in the laboratory: Neutrophils have "neutral" subtle granules; Eosinophils have prominent granules that stain readily with the acid dye eosin; and Basophils have prominent granules that stain readily basic (non acidic) dyes. This classification dates back to a time when certain structures could be identified in cells by histochemistry, but the functions of these intracellular structures were still not yet fathomed. However, the classification of granulocytes into neutrophils, eosinophils and basophils is still widely used (and quite useful). Granulocytopenia can therefore more specifically involve neutropenia (shortage of neutrophils), eosinopenia and/or basopenia. The term "neutropenia" is sometimes used interchangeably with granulocytopenia or agranulocytosis.
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Less than the normal number of granular leukocytes in the blood. SYN: granulopenia, hypogranulocytosis. [granulocyte + G. penia, poverty]

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gran·u·lo·cy·to·pe·nia .gran-yə-lō-.sīt-ə-'pē-nē-ə n deficiency of blood granulocytes esp AGRANULOCYTOSIS
gran·u·lo·cy·to·pe·nic -'pē-nik adj

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n.
a reduction in the number of granulocyte (a type of white cell) in the blood. See neutropenia.

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gran·u·lo·cy·to·pe·nia (gran″u-lo-si″to-peґne-ə) [granulocyte + -penia] reduction in the number of granular leukocytes in the blood. Cf. agranulocytosis. Called also granulopenia and hypogranulocytosis.

Medical dictionary. 2011.

Look at other dictionaries:

  • granulocytopenia — Low granulocyte number in circulating blood …   Dictionary of molecular biology

  • granulocytopenia — noun An abnormally low concentration of certain white blood cells called granulocytes in the blood. This condition reduces the bodys resistance to many infections …   Wiktionary

  • granulocytopenia — gran·u·lo·cy·to·pe·nia …   English syllables

  • granulocytopenia — n. a reduction in the number of granulocytes (a type of white cell) in the blood. See: neutropenia …   The new mediacal dictionary

  • granulocytopenia — A deficiency in the number of granulocytes, a type of white blood cell …   English dictionary of cancer terms

  • granulocytopenia — noun an acute blood disorder (often caused by radiation or drug therapy) characterized by severe reduction in granulocytes • Syn: ↑agranulocytosis, ↑agranulosis • Derivationally related forms: ↑agranulocytic (for: ↑agranulocytosis) …   Useful english dictionary

  • Гранулоцитопения (Granulocytopenia) — уменьшение количества гранулоцитов (разновидности лейкоцитов) в крови. См. Нейтропенш. Источник: Медицинский словарь …   Медицинские термины

  • гранулоцитопения — (granulocytopenia; гранулоцит + греч. penia бедность, недостаток) уменьшенное содержание гранулоцитов в периферической крови …   Большой медицинский словарь

  • Гранулоцитопени́я — (granulocytopenia; Гранулоцит + греч. penia бедность, недостаток) уменьшенное содержание гранулоцитов в периферической крови …   Медицинская энциклопедия

  • ГРАНУЛОЦИТОПЕНИЯ — (granulocytopenia) уменьшение количества гранулоцитов (разновидности лейкоцитов) в крови. См. Нейтропенш …   Толковый словарь по медицине

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