Hemoglobin S
The most common type of abnormal hemoglobin and the basis of sickle cell trait and sickle cell anemia. Hemoglobin S differs from normal adult hemoglobin (called hemoglobin A) only by a single amino acid substitution (a valine replacing a glutamine in the 6th position of the beta chain of globin). Recognition of this tiny change in the hemoglobin molecule marked the opening of molecular medicine.

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hemoglobin S n an abnormal hemoglobin occurring in the red blood cells in sickle-cell anemia and sickle-cell trait and differing from hemoglobin A in having a valine residue substituted for the glutamic-acid residue in position 6 of two of the four polypeptide chains making up the hemoglobin molecule

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the most common abnormal hemoglobin, having valine substituted for glutamic acid at position 6 of the β chain; the homozygous state results in sickle cell anemia, and the asymptomatic heterozygous state is called sickle cell trait.

Medical dictionary. 2011.

Look at other dictionaries:

  • hemoglobin S — hemoglobin S. См. гемоглобин S. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemoglobin S — noun : the hemoglobin occurring in the red blood cells in sickle cell anemia and sickle cell trait and differing from hemoglobin A in its lower solubility and lower isoelectric point …   Useful english dictionary

  • hemoglobin S — noun Date: 1954 an abnormal hemoglobin that occurs in the red blood cells in sickle cell anemia and sickle cell trait …   New Collegiate Dictionary

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  • Hemoglobin C — (abbreviated as Hb C or HbC ) is an abnormal hemoglobin with substitution of a lysine residue for glutamic acid residue at the 6th position of the β globin chain. [ [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 a=141900… …   Wikipedia

  • hemoglobin — [hē′mə glō΄bin, hem′əglō΄bin] n. [contr. (as if < HEMO ) < earlier haematoglobulin: see HEMATO & GLOBULIN] 1. the red coloring matter of the red blood corpuscles of vertebrates, a protein yielding heme and globin on hydrolysis: it carries… …   English World dictionary

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