Hemophagocytic lymphohistiocytosis
A rare, cancer-like disorder in which both histiocytes and lymphocytes start to proliferate and attack body tissues or organs. It can be an inherited condition, or it can occur as a result of immunosuppression (as in organ transplants) or infection. Most patients are young children. Treatment is by chemotherapy, and in some cases bone-marrow transplantation. See also histiocytosis.

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any of several closely related disorders involving both lymphocytosis and histiocytosis, with excessive hemophagocytosis in the lymphoreticular system or the central nervous system; they are usually seen in children secondary to infection and are often fatal; they can also be secondary to rheumatologic or other conditions, or can be familial (familial hemophagocytic l.). Called also hemophagocytic syndrome and macrophage activation syndrome.

Medical dictionary. 2011.

Look at other dictionaries:

  • Hemophagocytic lymphohistiocytosis — Infobox Disease Name = PAGENAME Caption = Light microscopic image of bone marrow showing stromal macrophages containing numerous red blood cells in their cytoplasm DiseasesDB = 31418 ICD10 = ICD10|D|76|1|d|70 ICD9 = ICD9|288.4 ICDO = OMIM =… …   Wikipedia

  • hemophagocytic lymphohistiocytosis — HLH. A rare disorder in which histiocytes and lymphocytes (types of white blood cells) build up in organs including the skin, spleen, and liver, and destroy other blood cells. HLH may be inherited or caused by certain conditions or diseases,… …   English dictionary of cancer terms

  • familial hemophagocytic lymphohistiocytosis — an autosomal recessive, genetically heterogeneous type of hemophagocytic lymphohistiocytosis; it is characterized by anemia, granulocytopenia, thrombocytopenia, intense phagocytosis of red blood cells, diffuse proliferation of histiocytes of… …   Medical dictionary

  • lymphohistiocytosis — Proliferation or infiltration of lymphocytes and histiocytes. familial erythrophagocytic l. (FEL) SYN: familial hemophagocytic l.. familial hemophagocytic l. (FMLH) an extremely rare, usually fatal disease of childhood characterized by multiorgan …   Medical dictionary

  • hemophagocytic syndrome — see under lymphohistiocytosis …   Medical dictionary

  • familial hemophagocytic reticulosis — familial histiocytic reticulosis familial hemophagocytic lymphohistiocytosis …   Medical dictionary

  • erythrophagocytic lymphohistiocytosis — hemophagocytic l …   Medical dictionary

  • histiocytic medullary reticulosis — hemophagocytic lymphohistiocytosis …   Medical dictionary

  • macrophage activation syndrome — hemophagocytic lymphohistiocytosis …   Medical dictionary

  • HLH — Hemophagocytic lymphohistiocytosis. A rare disorder in which histiocytes and lymphocytes (types of white blood cells) build up in organs including the skin, spleen, and liver, and destroy other blood cells. HLH may be inherited or caused by… …   English dictionary of cancer terms

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