Ichthyosis vulgaris
A genetic skin disease that is inherited as an autosomal (nonsex-linked) trait and is characterized by scaly (fishlike) areas of skin. The first scaly skin problems usually appear after 3 months of age. The palms and soles are often affected. Areas that tend to be spared include the axillae (the armpits), the antecubital fossa (the inside area at the bend of the elbow) and the popliteal fossa (behind the knee). A considerable proportion of persons with this disease have asthma, eczema or hay fever. The gene responsible for this disease has been mapped to chromosome band 1q21. The product of this gene is thought to be a substance called filaggrin (abbreviated FLG) which may act as the "keratin matrix protein" in cells of the stratum corneum, one of the layers of the skin. The disease is also known as ichthyosis simplex.

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ichthyosis vul·gar·is -.vəl-'gar-əs n the common hereditary form of ichthyosis

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the most common form of ichthyosis, an autosomal dominant disorder caused by mutation in the FLG gene (locus: 1q21), which encodes filaggrin. Onset is after the first year of life, often near puberty. It is characterized by prominent fine scaling, mainly on the extensor surfaces of the limbs and back, with flexures, the abdomen, and the face usually being spared; there is accentuated marking with creases on the palms and soles, and sometimes atopy. Called also i. simplex.

Ichthyosis vulgaris with typical fishlike scales.


Medical dictionary. 2011.

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