Inhibitor, ACE
A drug that inhibits angiotensin converting enzyme (ACE). This enzyme is important to the formation of angiotensin II which causes arteries in the body to constrict and thereby raises blood pressure. ACE inhibitors lower the blood pressure by inhibiting the formation of angiotensin II thus allowing arteries to relax (dilate). Relaxing the arteries not only lowers blood pressure, but also improves the pumping efficiency of a failing heart and improves cardiac output in patients with heart failure. ACE inhibitors are therefore used for blood pressure control and congestive heart failure. The currently available ACA inhibitors include: {{}}benazepril (brand name: LOTENSIN), {{}}captopril (brand name: CAPOTEN), {{}}lisinopril (brand names: ZESTRIL and PRINIVIL), {{}}quinapril (brand name: ACCUPRIL), and ramipril (brand name: ALTACE). ACE inhibitors may slow the progress of diabetic kidney disease in middle-aged persons with type 2 diabetes. Some (but not all) experts have therefore recommended giving ACE inhibitors to all middle-aged type 2 diabetics. (Reference: Annals of Internal Medicine 1999;131:660-667, 707-708.) Historically, it is interesting that the ACE inhibitors were originally developed from the venom of a poisonous Brazilian snake.

Medical dictionary. 2011.

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  • ACE inhibitor — [ā΄sē΄ē′, ās] n. [a( ngiotensin ) c( onverting) e( nzyme)] any of a class of drugs, including captopril, that inhibit or block the action of an enzyme (ACE) that produces the powerful vasoconstrictor angiotensin, used to treat high blood pressure …   English World dictionary

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  • ACE inhibitors drug design — The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This lead to the development of Captopril, the first ACE inhibitor. When… …   Wikipedia

  • ACE inhibitor — A drug that inhibits ACE (angiotensin converting enzyme) which is important to the formation of angiotensin II. Angiotensin II causes arteries in the body to constrict and thereby raises the blood pressure. ACE inhibitors lower the blood pressure …   Medical dictionary

  • ACE inhibitor — noun an antihypertensive drug that blocks the formation of angiotensin II in the kidney, leading to relaxation of the arteries; promotes the excretion of salt and water by inhibiting the activity of the angiotensin converting enzyme; also used to …   Useful english dictionary

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