- The first sulfonamide used for its chemotherapeutic effect in infections caused by some β-hemolytic streptococci, meningococci, gonococci, Clostridium welchii, and in certain infections of the urinary tract, especially those due to Escherichia coli and Proteus vulgaris; less effective than sulfapyridine in the treatment of pneumococcic, staphylococcic, and Klebsiella pneumoniae infections. Toxic manifestations include acidosis, cyanosis, hemolytic anemia, and agranulocytosis.
* * *sul·fa·nil·amide or chiefly Brit sul·pha·nil·amide .səl-fə-'nil-ə-.mīd, -məd n a crystalline sulfonamide C6H8N2O3S that is the amide of sulfanilic acid and the parent compound of most of the sulfa drugs
* * *sul·fa·nil·a·mide (sul″fə-nilґə-mīd) a potent antibacterial compound, the first of the sulfonamides discovered. Formerly used in the treatment of various infections, it has been replaced as a systemic agent by more effective and less toxic derivatives, and by antibiotics; it is still used vaginally in the treatment of vulvovaginal candidiasis.
Medical dictionary. 2011.