superantigen

superantigen
An antigen that interacts with the T-cell receptor in a domain outside the antigen recognition site. This interaction induces the activation of larger numbers of T cells than are induced by antigens that are presented in the antigen recognition site leading to the release of numerous cytokines. SEE ALSO: antigen.

* * *

su·per·an·ti·gen -'ant-i-jən n a substance (as an enterotoxin) that acts as an antigen capable of stimulating much larger numbers of T cells than an ordinary antigen
su·per·an·ti·gen·ic -.ant-i-'jen-ik adj

* * *

su·per·an·ti·gen (soo″pər-anґtĭ-jən) any of a group of powerful antigens occurring in various bacteria and viruses that binds outside of the normal T cell receptor site and is able to react with multiple T cell receptor molecules of a given β chain variable element, regardless of their α chain sequence, thus activating T cells nonspecifically. Included are staphylococcal enterotoxins and toxins causing toxic shock syndrome and exfoliative dermatitis.

Medical dictionary. 2011.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • Superantigen — [ thumb|Figure 1. Schematic of Superantigen stimulation compared to normal antigen presentation and activation [2] .] Superantigens (SAgs) are secreted proteins (exotoxins) that exhibit highly potent lymphocyte transforming (mitogenic) activity… …   Wikipedia

  • Superantigen — Superantigene (SAG) umfassen einen Komplex von Toxinen, deren Verhalten weitab von dem Verhalten konventioneller Antigene liegt. Dennoch haben sie antigene Eigenschaften. SAG bewirken eine Dysregulation des Immunsystems, die immer in gleicher… …   Deutsch Wikipedia

  • superantigen — Antigens, mostly of microbial origin, that activate all T lymphocytes that have a T cell receptor with a particular V b sequence; as a consequence superantigens activate large numbers of T cells. Are presented on MHC Class II but are not… …   Dictionary of molecular biology

  • superantigen — Superantigens are bacterial proteins that stimulate the immune system much more extensively than do normal antigens. They stimulate T cells to proliferate nonspecifically through simultaneous interaction with class II MHC proteins on antigen… …   Dictionary of microbiology

  • superantigen — noun An antigen, which has a powerful interaction with T lymphocytes …   Wiktionary

  • superantigen — su·per·antigen …   English syllables

  • superantigen — /supəˈræntidʒən/ (say soohpuh ranteejuhn) noun any of various powerful antigens which initiate a surge of T cells resulting in acute disease such as toxic shock syndrome, or a chronic inflammation as experienced in rheumatic fever …  

  • superantigen — ˌ noun Etymology: super + antigen : a substance (as an enterotoxin) that acts as an antigen capable of stimulating much larger numbers of T cells than an ordinary antigen …   Useful english dictionary

  • Naptumomab estafenatox — ? Monoclonal antibody Type Fab fragment Source Mouse Target 5T4 Clinical data Pregnancy cat.  ? Legal status …   Wikipedia

  • Tumoren: Behandlung —   Einige bösartige Tumoren produzieren vermehrt bestimmte Eiweißstoffe (Tumormarker), die im Blut nachgewiesen werden können. Eine erhöhte Konzentration eines dieser Tumormarker kann deshalb auf einen Tumor hindeuten. Allerdings wird ein… …   Universal-Lexikon

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”