tachyphylaxis

tachyphylaxis
Rapid appearance of progressive decrease in response to a given dose following repetitive administration of a pharmacologically or physiologically active substance. [tachy- + G. phylaxis, protection]

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tachy·phy·lax·is .tak-i-fi-'lak-səs n, pl -lax·es -.sēz diminished response to later increments in a sequence of applications of a physiologically active substance (as the diminished pressor response that follows repeated injections of renin)

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n.
a falling-off in the effects produced by a drug during continuous use or constantly repeated administration, common in drugs that act on the nervous system.

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tachy·phy·lax·is (tak″e-fə-lakґsis) [tachy + phylaxis] 1. rapid immunization against the effect of toxic doses of an extract or serum by previous injection of small doses. 2. rapidly decreasing response to a drug or physiologically active agent after administration of a few doses.

Medical dictionary. 2011.

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  • Tachyphylaxis — is a medical term describing a rapidly decreasing response to a drug following administration of the initial doses.ExamplesExamples of tachyphylaxes are the following:*Nitroglycerine demonstrates tachyphylaxis, requiring drug free intervals when… …   Wikipedia

  • Tachyphylaxis — In der Pharmakologie versteht man unter Toleranz die Gewöhnung an einen Wirkstoff, wobei dessen Wirkung durch wiederholte bzw. chronische Einnahme über einen bestimmten Zeitraum abnimmt. In vielen, aber nicht allen Fällen kann zur Erzielung der… …   Deutsch Wikipedia

  • tachyphylaxis — A decrease in the response to an agonist following repeated exposure. Can arise through a variety of mechanisms …   Dictionary of molecular biology

  • tachyphylaxis — tachyphylactic /tak euh fi lak tik/, adj. /tak euh fi lak sis/, n. 1. Med. immediate, temporary immunization against the effects of injection of a toxic extract owing to previous small injections of the same extract. 2. a decreased response to a… …   Universalium

  • tachyphylaxis — noun A rapidly decreasing response to a drug following administration of the initial doses …   Wiktionary

  • tachyphylaxis — n. reduced responsiveness (Medicine) …   English contemporary dictionary

  • tachyphylaxis — [ˌtakɪfɪ laksɪs] noun Medicine rapidly diminishing response to successive doses of a drug, rendering it less effective …   English new terms dictionary

  • tachyphylaxis — tachy·phy·lax·is …   English syllables

  • tachyphylaxis — n. a falling off in the effects produced by a drug during continuous use or constantly repeated administration, common in drugs that act on the nervous system …   The new mediacal dictionary

  • tachyphylaxis —   n. rapid development of immunity to the effects of a drug, especially to those of a poison through previous ingestion of small amount of same …   Dictionary of difficult words

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