Angiostatin
Angiostatin is a piece (a fragment) of a protein, plasminogen, used normally in blood clotting. This fragment is normally secreted by tumors. It appears to halt the process of developing new blood vessels (angiogenesis) which is necessary to tumor development. Angiostatin may, it is hoped, represent a prototype for a new class of agents with which to treat cancer.

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n.

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an·gio·stat·in (an″je-o-statґin) 1. an angiogenesis inhibitor. 2. a 38-kD fragment of plasminogen that inhibits the growth of new blood vessels; it is produced by proteolytic cleavage of plasminogen and by certain types of tumor cells.

Medical dictionary. 2011.

Look at other dictionaries:

  • Angiostatin — is a naturally occurring protein found in several animal species, including humans. It is an endogenous angiogenesis inhibitor (i.e., it blocks the growth of new blood vessels), and it is currently undergoing clinical trials for its use in… …   Wikipedia

  • angiostatin — /an ji ō statˈin/ noun A protein that occurs naturally in plasminogen, believed to be effective in limiting the growth of cancerous tumours ORIGIN: ↑angio , ↑ stat and ↑ in (1) …   Useful english dictionary

  • angiostatin — A protein normally made by the body. It can also be made in the laboratory, and is being studied in the treatment of cancer. Angiostatin may prevent the growth of new blood vessels from the surrounding tissue to a solid tumor. It belongs to the… …   English dictionary of cancer terms

  • angiostatin — Inhibitor of angiogenesis …   Dictionary of molecular biology

  • angiostatin — an·gi·o·stat·in (ăn jē ō stătʹn) n. A naturally occurring protein that is a specific inhibitor of endothelial proliferation and a potent angiogenesis inhibitor. It is under investigation as a potential cancer therapy.   [angiogenesis + stat +… …   Universalium

  • angiostatin — noun A protein that inhibits angiogenesis; it is used to inhibit the growth of new blood vessels in tumours …   Wiktionary

  • Angiostatin — An|gio|sta|tin 〈n. 11; Med.〉 Stoff, der die Neubildung von Blutgefäßen hemmt, wird in der Krebstherapie angewendet [<grch. aggeion „Gefäß“ + statos „stehend“] …   Universal-Lexikon

  • angiostatin — /ændʒioʊˈsteɪtən/ (say anjeeoh staytuhn) noun a naturally occurring protein in animals, which blocks the production of new blood vessels; used in cancer therapy. {angio + stat + in1} …   Australian English dictionary

  • Life Sciences — ▪ 2009 Introduction Zoology       In 2008 several zoological studies provided new insights into how species life history traits (such as the timing of reproduction or the length of life of adult individuals) are derived in part as responses to… …   Universalium

  • Angiostatina — Saltar a navegación, búsqueda La angiostatina es una proteína encontrada en varias especies animales, incluyendo humanos. Es un inhibidor endógeno de la angiogénesis (i.e., bloquea el crecimiento de nuevos vasos sanguíneos), y es actualmente… …   Wikipedia Español

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