LCHAD deficiency
Acute fatty liver of pregnancy (AFLP) has been found to be associated in some cases with an abnormality of fatty-acid metabolism. This abnormality is a deficiency of the enzyme long-chain-3-hydroxyacyl-CoA dehydrogenease (LCHAD). The mother (and father) have 50% of normal LCHAD activity and the fetus has no LCHAD activity. The metabolic disease in the baby's liver apparently causes the fatty liver disease in the mother. In cases of AFLP due to LCHAD deficiency, there is a 25% (or greater) risk of AFLP in each pregnancy.

Medical dictionary. 2011.

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  • Deficiency, LCHAD — Acute fatty liver of pregnancy (AFLP) has been found to be associated in some cases with an abnormality of fatty acid metabolism. This abnormality is a deficiency of the enzyme long chain 3 hydroxyacyl CoA dehydrogenease (LCHAD). The mother (and… …   Medical dictionary

  • Deficiency, long-chain-3-hydroxyacyl-CoA dehydrogenase — Acute fatty liver of pregnancy (AFLP) has been found to be associated in some cases with an abnormality of fatty acid metabolism. This abnormality is a deficiency of the enzyme long chain 3 hydroxyacyl CoA dehydrogenase (LCHAD). The mother (and… …   Medical dictionary

  • Long-chain-3-hydroxyacyl-CoA dehydrogenase deficiency — Acute fatty liver of pregnancy (AFLP) has been found to be associated in some cases with an abnormality of fatty acid metabolism. This abnormality is a deficiency of the enzyme long chain 3 hydroxyacyl CoA dehydrogenase (LCHAD). The mother (and… …   Medical dictionary

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  • Acute fatty liver of pregnancy — Liver failure in late pregnancy, usually from unknown cause. Acute fatty liver of pregnancy (AFLP) typically occurs in first time pregnancies in the last trimester. AFLP causes nausea and vomiting, abdominal pain especially in the upper abdomen… …   Medical dictionary

  • Fatty liver of pregnancy, acute — Liver failure in late pregnancy, usually from unknown cause. Acute fatty liver of pregnancy (AFLP) typically occurs in first time pregnancies in the last trimester. AFLP causes nausea and vomiting, abdominal pain especially in the upper abdomen… …   Medical dictionary

  • Liver of pregnancy, acute fatty — Liver failure in late pregnancy, usually from unknown cause. Acute fatty liver of pregnancy (AFLP) typically occurs in first time pregnancies in the last trimester. AFLP causes nausea and vomiting, abdominal pain especially in the upper abdomen… …   Medical dictionary

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