Leukoencephalopathy with vanishing white matter
An inherited brain disease that occurs mainly in children. and follows a chronic progressive course with additional episodes of rapid deterioration following stress from febrile infection or minor head trauma. Leukoencephalopathy with vanishing white matter (VWM) is due to mutations in either of two genes — in either the EIF2B5 gene on chromosome 3q27 or the EIF2B2 gene on chromosome 14q24. These two genes encode the epsilon and beta subunits, respectively, of the translation initiation factor eIF2B. Since eIF2B plays an essential role in the regulation of translation under different conditions, including stress, this may explain the rapid deterioration in persons with VWM under stress. The disease is also known as childhood ataxia with central nervous system hypomyelinization.

Medical dictionary. 2011.

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  • Leukoencephalopathy with vanishing white matter — Classification and external resources OMIM 603896 Leukoencephalopathy with vanishing white matter (VWM disease) is an autosomal recessive neurological disease. The cause of the disease are mutations in any of the 5 genes encoding subunits of the… …   Wikipedia

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  • Progressive multifocal leukoencephalopathy — ] natalizumabcite web |url=http://www.newscientist.com/channel/health/dn8796.html |title=Potential risks of powerful MS drug are weighed health 02 March 2006 New Scientist |accessdate=2008 01 28 |format= |work=] , chemotherapy cite journal… …   Wikipedia

  • Childhood ataxia with central nervous system hypomyelinization — An inherited brain disease that occurs mainly in children and follows a chronic progressive course with additional episodes of rapid deterioration following stress from febrile infection or minor head trauma. The disease is due to mutations in… …   Medical dictionary

  • VWM — Leukoencephalopathy with vanishing white matter, an inherited brain disease that occurs mainly in children. and follows a chronic progressive course with additional episodes of rapid deterioration following stress from febrile infection or minor… …   Medical dictionary

  • EIF2B5 — Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa, also known as EIF2B5, is a human gene.cite web | title = Entrez Gene: EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa| url =… …   Wikipedia

  • EIF2B1 — Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa, also known as EIF2B1, is a human gene.cite web | title = Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa| url =… …   Wikipedia

  • EIF2B4 — Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa, also known as EIF2B4, is a human gene.cite web | title = Entrez Gene: EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa| url =… …   Wikipedia

  • EIF2B3 — Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa, also known as EIF2B3, is a human gene.cite web | title = Entrez Gene: EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa| url =… …   Wikipedia

  • EIF2B2 — Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa, also known as EIF2B2, is a human gene.cite web | title = Entrez Gene: EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa| url =… …   Wikipedia

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