transglutaminase
A group of enzymes that catalyze the calcium-dependent acyl transfer reaction in which the amide moiety of peptide-bound glutaminyl residues serve as acyl donor; a specific t. covalently cross-links fibrin molecules between glutamine and the ε-amino group of a lysyl residue, thus producing a more stable fibrin clot; another t. participates in the formation of the chemically resistant envelope of the stratum corneum during terminal differentiation of keratinocytes.

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trans·glu·ta·min·ase -'glüt-ə-mə-.nās, -glü-'tam-ə-.nāz n a clotting factor that is a variant of factor XIII and that promotes the formation of cross-links between strands of fibrin

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trans·glu·tam·in·ase (trans″gloo-tamґin-ās) protein-glutamine γ-glutamyltransferase.

Medical dictionary. 2011.

Look at other dictionaries:

  • Transglutaminase — Transglutaminases are a family of enzymes (EC 2.3.2.13) that catalyze the formation of a covalent bond between a free amine group (e.g., protein or peptide bound lysine) and the gamma carboxamid group of protein or peptide bound glutamine. Bonds… …   Wikipedia

  • Transglutaminase — La transglutaminase est une enzyme (EC 2.3.2.13) qui catalyse la formation de liaisons covalentes entre des groupements amines libres (ex. : lysines) et le groupement gamma carboxamide des glutamines. Les liaisons formées par la… …   Wikipédia en Français

  • Transglutaminase — Protein Glutamin γ Glutamyltransferase Bezeichner Externe IDs CAS Nummer:  …   Deutsch Wikipedia

  • transglutaminase — An important extracellular enzyme that catalyses the formation of an amide bond between side chain glutamine and side chain lysine residues in proteins with the elimination of ammonia. The linkage is stable and plays an important role in many… …   Dictionary of molecular biology

  • transglutaminase — noun Any of a family of enzymes that catalyze the reaction of lysine and glutamine groups in proteins and have a function in blood coagulation …   Wiktionary

  • Keratinocyte transglutaminase — Transglutaminase 1 (K polypeptide epidermal type I, protein glutamine gamma glutamyltransferase), also known as TGM1, is a human gene.cite web | title = Entrez Gene: TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein glutamine gamma …   Wikipedia

  • Anti-transglutaminase antibodies — AutoAbBox Autoantigen = transglutaminase SharedInfo = Yes CommentShared Answer Yes only if true SI Gene = SI Organ = SI Tissue = SI Cell = SI Also = SI Disease = SI Class = IgA, IgG SI IgGSubclass = SI HLA1 = DQ2.5 SI HLA2 = DQ8 SI HLA3 =… …   Wikipedia

  • Tissue transglutaminase — (abbreviated as TG2 or tTG) is an enzyme (EC number|2.3.2.13) of the transglutaminase family. Like other transglutaminases, it crosslinks proteins between an epsilon; amino group of a lysine residue and a gamma; carboxamide group of glutamine… …   Wikipedia

  • TGase — transglutaminase …   Medical dictionary

  • TGase — • transglutaminase …   Dictionary of medical acronyms & abbreviations

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