Annexin V
Annexin V is the cause of a syndrome called the antiphospholipid antibody syndrome with abnormal blood clotting. The annexins are a family of proteins first described in 1990. All of the annexin proteins share the property of binding calcium and phospholipids. Annexin V normally forms a shield around certain phospholipid molecules that blocks their entry into coagulation (clotting) reactions. In the antiphospholipid antibody syndrome, the formation of this shield is disrupted by the abnormal antibodies. Without the shield, there is an increased quantity of phospholipid molecules on cell membranes, speeding up coagulation reactions and causing the abnormal blood clotting characteristic of the antiphospholipid antibody syndrome.

Medical dictionary. 2011.

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  • Annexin — Pfam box Symbol = Annexin Name = width = 220 caption = Structure of human annexin III. Pfam= PF00191 InterPro= IPR001464 SMART= PROSITE= PDOC00195 SCOP = 2ran TCDB = 1.A.31 OPM family= 43 OPM protein= 1w3w PDB=PDB3|1n00A:14 79 PDB3|1dk5B:15 80… …   Wikipedia

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  • Antiphospholipid-Syndrom — Klassifikation nach ICD 10 D68.6 Sonstige Thrombophilien …   Deutsch Wikipedia

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  • Annexins — The annexins are a family of proteins first described in 1990. All of the annexin proteins share the property of binding calcium and phospholipids. The antiphospholipid antibody syndrome is due to a deficiency of annexin V. Annexin V normally… …   Medical dictionary

  • 7-AAD — Strukturformel Allgemeines Name 7 Aminoactinomycin Andere Namen 7 AAD …   Deutsch Wikipedia

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