Macrolide
One in a class of antibiotics that includes Biaxin, Clarithromycin, Ery-Tab, and Erythromycin. The macrolides inhibit the growth of bacteria and are often prescribed to treat rather common bacterial infections. In more technical terms, the macrolides are a group of antibiotics produced by various strains of Streptomyces (spore forming bacteria that grow slowly in soil or water as a branching filamentous mycelium similar to that of fungi) and have a complex chemical (macrocyclic) structure. They act by inhibiting protein synthesis, specifically by blocking the 50S ribosomal subunit. They are broad spectrum antibiotics.
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A natural lactone, whose ring is large, usually of 14–20 atoms; several antibiotics, including erythromycin, are macrolides. They inhibit protein biosynthesis.

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mac·ro·lide 'mak-rə-.līd n any of several antibiotics (as erythromycin) containing a macrocyclic lactone ring that are produced by actinomycetes of the genus Streptomyces and inhibit bacterial protein synthesis

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mac·ro·lide (makґro-līd) 1. a chemical compound characterized by a large lactone ring containing multiple keto and hydroxyl groups. 2. any of a large group of antibacterial antibiotics containing a macrolide ring linked glycosidically to one or more sugars; they are produced by certain species of Streptomyces and inhibit protein synthesis by binding to the 50S subunits of 70S ribosomes. Examples include erythromycin, azithromycin, and clarithromycin.

Medical dictionary. 2011.

Look at other dictionaries:

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  • macrolide — noun a) a macrocyclic lactone with a ring of at least twelve atoms b) Any of a group of antibiotics having this structure …   Wiktionary

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  • macrolide — pl.m. macrolidi …   Dizionario dei sinonimi e contrari

  • macrolide — mac·ro·lide …   English syllables

  • macrolide — ˈmakrəˌlīd noun ( s) Etymology: macrocyclic + lactone + ide : any of several antibiotics (as erythromycin) containing a macrocyclic lactone ring that are produced by actinomycetes of the genus Streptomyces and inhibit bacterial protein synthesis …   Useful english dictionary

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