Membrane attack complex
An abnormal activation of the complement (protein) portion of the blood, forming a cascade reaction that brings blood proteins together, binds them to the cell wall, and then inserts them through the cell membrane. MAC formation allows water, ions, and other small molecules to move freely into and out of a cell, and quickly results in cell death. Abbreviated MAC.

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(MAC) C5b,6,7,8,9; the pentamolecular complex that is the cytolytic agent of the complement system; see C5b,6,7,8,9, under complement.

Medical dictionary. 2011.

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